PRODUCTION OF THERMOREVERSIBLE HYDROGELS FOR THERAPEUTIC APPLICATIONS
2 Assignments
0 Petitions
Accused Products
Abstract
A method is disclosed for production of a sterile thermoreversible hydrogel characterized by a known temperature Tmin at which the viscosity reaches at least a local minimum. In a preferred embodiment of the invention, the method comprises dissolving the components in water within ±4° C. of Tmin; forming the thermoreversible hydrogel; and filtering the thermoreversible hydrogel at Tmin. The final sterilization can be obtained by filtering under aseptic conditions or by autoclaving or irradiation of the final product. In other embodiments, the components of the gel are dissolved in a sufficiently large quantity of water that reduces the gel viscosity or precludes formation of a thermoreversible hydrogel, and sufficient water is then removed under vacuum to produce the final thermoreversible hydrogel.
8 Citations
93 Claims
-
1-73. -73. (canceled)
-
74. A method for production of a sterile thermoreversible hydrogel, said hydrogel having a temperature Tmin, lower than its gelation temperature, at which the viscosity reaches an at least local minimum, characterized in that said process comprises:
-
dissolving in water, within a predetermined temperature range relative to said Tmin, components of said sterile thermoreversible hydrogel; mixing said components until a thermoreversible gel is obtained; and
,filtering said thermoreversible gel within a predetermined temperature of said Tmin. - View Dependent Claims (76, 78, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 92)
-
-
75. A method for production of a sterile thermoreversible hydrogel, said hydrogel having a temperature Tmin, at which the viscosity reaches an at least local minimum, characterized in that said process comprises:
-
a. dissolving components of said sterile thermoreversible hydrogel in a quantity of water sufficiently large to prevent formation of a gel with thermal gelation characteristics; b. filtering said gel; and c. concentrating said gel by evaporating at least part of said water under vacuum, thereby forming a thermoreversible gel. - View Dependent Claims (77, 79, 91, 93)
-
Specification