NASAL ADMINISTRATION
First Claim
1. A method of delivering substance to the central nervous system (CNS) of a subject, the method comprising the steps of:
- inserting a nosepiece unit into a nasal airway of a subject, wherein the nosepiece unit comprises an outlet unit which includes a nozzle for delivering substance into the nasal airway of the subject; and
delivering a dose of substance to the nozzle;
wherein at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway which is posterior of the nasal valve and above the inferior meatus, thereby providing a CNS effect which is significantly greater than that predicted from a counterpart blood plasma concentration of the substance;
wherein the substance comprises sumatriptan or its pharmaceutically-acceptable derivatives or analogues.
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Accused Products
Abstract
A delivery device for and method of providing for delivery of substance to the central nervous system (CNS) of a subject, the delivery device comprising: a nosepiece unit for insertion into a nasal airway of a subject and comprising an outlet unit which includes a nozzle for delivering substance into the nasal airway of the subject; and a substance supply unit which is operable to deliver a dose of substance to the nozzle; wherein the delivery device is configured such that at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway, thereby providing a CNS concentration of the substance, and hence CNS effect, which is significantly greater than that which would be predicted from a counterpart blood plasma concentration of the substance.
56 Citations
14 Claims
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1. A method of delivering substance to the central nervous system (CNS) of a subject, the method comprising the steps of:
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inserting a nosepiece unit into a nasal airway of a subject, wherein the nosepiece unit comprises an outlet unit which includes a nozzle for delivering substance into the nasal airway of the subject; and delivering a dose of substance to the nozzle; wherein at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway which is posterior of the nasal valve and above the inferior meatus, thereby providing a CNS effect which is significantly greater than that predicted from a counterpart blood plasma concentration of the substance; wherein the substance comprises sumatriptan or its pharmaceutically-acceptable derivatives or analogues. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of delivering substance to the central nervous system (CNS) of a subject, the method comprising the steps of:
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inserting a nosepiece unit into a nasal airway of a subject, wherein the nosepiece unit comprises an outlet unit which includes a nozzle for delivering substance into the nasal airway of the subject, wherein the nozzle is configured to deliver a powder aerosol; and the subject exhaling through a mouthpiece to cause closure of the oropharyngeal velum of the subject, wherein the outlet unit is fluidly connected to the mouthpiece, whereby exhaled air from an exhalation breath of the subject is delivered through the nosepiece unit into the nasal airway of the subject to entrain and deliver a dose of substance to the nozzle; wherein the substance comprises sumatriptan or its pharmaceutically-acceptable derivatives or analogues; wherein at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway which is posterior of the nasal valve and above the inferior meatus, thereby providing a CNS effect which is significantly greater than that predicted from a counterpart blood plasma concentration of the substance.
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Specification