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NASAL ADMINISTRATION

  • US 20140144443A1
  • Filed: 01/29/2014
  • Published: 05/29/2014
  • Est. Priority Date: 01/19/2006
  • Status: Abandoned Application
First Claim
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1. A method of delivering substance to the central nervous system (CNS) of a subject, the method comprising the steps of:

  • inserting a nosepiece unit into a nasal airway of a subject, wherein the nosepiece unit comprises an outlet unit which includes a nozzle for delivering substance into the nasal airway of the subject; and

    delivering a dose of substance to the nozzle;

    wherein at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway which is posterior of the nasal valve and above the inferior meatus, thereby providing a CNS effect which is significantly greater than that predicted from a counterpart blood plasma concentration of the substance;

    wherein the substance comprises sumatriptan or its pharmaceutically-acceptable derivatives or analogues.

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