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Compositions and Methods for Modulating Metabolic Pathways

  • US 20140148488A1
  • Filed: 04/19/2013
  • Published: 05/29/2014
  • Est. Priority Date: 07/15/2011
  • Status: Active Grant
First Claim
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1. A composition comprising:

  • (a) at least about 500 mg of leucine and/or at least about 200 mg of one or more metabolites thereof, wherein the one or more leucine metabolites are selected from the group consisting of keto-isocaproic acid (KIC), alpha-hydroxy-isocaproic acid, and HMB;

    (b) at least about 10 mg of a sirtuin pathway activator; and

    (c) an anti-diabetic agent selected from the group consisting of biguanide and thiazolidinedione.

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