POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS
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Abstract
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
13 Citations
28 Claims
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1-20. -20. (canceled)
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21. A system for measurement of an analyte concentration, the system comprising:
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an implantable sensor comprising a sensing region configured to continuously produce in vivo sensor data indicative of an analyte concentration in a host, wherein the sensor further comprises a membrane located over the sensing region, wherein the membrane comprises a layer configured to reduce a flux of the analyte therethrough, wherein the layer comprises a material that is a polymer produced by a reaction of an isocyanate; a processor configured to process sensor data; and a user interface configured to display information corresponding to continuous sensor data; wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL to 400 mg/dL, a level of accuracy corresponding to a mean absolute relative difference of less than 10% over a sensor session length of from 3 to 7 days, wherein one or more reference measurements used to calculate the mean absolute relative difference are determined by analysis of blood. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28)
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Specification