DEVICE AND METHOD FOR SALVAGING MYOCARDIUM FOLLOWING HEART ATTACK

• US 20140148735A1
• Filed: 10/15/2013
• Published: 05/29/2014
• Est. Priority Date: 11/28/2012
• Status: Abandoned Application

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: NAU, WILLIAM H. Jr.
• Application Number:
  US14/054,019
• Publication Number:
  US 20140148735A1
• Time in Patent Office: Days
• US Class Current: 601/3
• CPC Class Codes: A61B 18/12 by passing a current through the tissue to be heated, e.g. high-frequency current
• CPC Class Codes: A61B 2018/00351 Heart
• CPC Class Codes: A61B 2090/0803 Counting the number of times an instrument is used
• CPC Class Codes: A61F 2007/0071 using a resistor, e.g. near the spot to be heated
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities
• CPC Class Codes: A61M 2025/0087 Multiple injection needles protruding laterally from the distal tip
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 2007/0043 intra-cavitary
• CPC Class Codes: A61N 5/025 Warming the body, e.g. hyperthermia treatment
• CPC Class Codes: A61N 5/0625 Warming the body, e.g. hyperthermia treatment
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: A61N 7/022 intracavitary

Abstract

Methods, systems, and devices are described for treating ischemia in heart tissue after a heart attack. A method includes providing a heat treatment device comprising a heating element, positioning the heating element in proximity to the heart tissue, and heating the heart tissue with the heating element to generate release of heat shock proteins in the heart tissue. The heat shock proteins may also be provided via delivery of a drug. The heat shock proteins can provide myocardial protection for the heart tissue.

Claims

1. A method of treating ischemia in heart tissue after a heart attack, the method comprising:

providing a heat treatment device comprising a heating element;

positioning the heating element in proximity to the heart tissue;

heating the heart tissue with the heating element to generate release of heat shock proteins in the heart tissue, the heat shock proteins providing myocardial protection for the heart tissue.

2. The method of claim 1, wherein heating the heart tissue includes directing ultrasound waves into the heart tissue.

3. The method of claim 2, wherein the ultrasound waves have a frequency in the range of about 1 MHz to about 10 MHz.

4. The method of claim 2, further comprising delivering a drug to the heart tissue, the drug comprising heat shock proteins.

5. The method of claim 4, further comprising driving the drug into the heart tissue with the ultrasound waves.

6. The method of claim 4, further comprising injecting the drug into the heat tissue.

7. The method of claim 4, wherein the drug comprises an adenovirus vector.

8. A method of providing myocardial protection in a heart after myocardial infarction, the method comprising:

providing a heart tissue treatment device;

positioning the heart tissue treatment device in proximity to the heart; and

utilizing the heart tissue treatment device to provide heat shock proteins to tissue of the heart for myocardial protection.

9. The method of claim 8, wherein positioning the heart tissue treatment device includes positioning a portion of the heart tissue treatment device in contact with an exterior surface of the heart.

10. The method of claim 8, further comprising heating the tissue using the heart tissue treatment device to generate the heat shock proteins.

11. The method of claim 8, wherein positioning the heart tissue treatment device includes inserting a portion of the heart tissue treatment device through a vessel into the heart.

12. The method of claim 8, further comprising providing a fluid interface between the heart tissue treatment device and the tissue of the heart.

13. A method of treating heart tissue damaged during a heart attack, the method comprising:

reperfusing an artery of the heart to create blood flow to the heart tissue;

heating the heart tissue to a temperature no more than 7°

C. above body temperature to trigger release of heat shock proteins in the heart tissue.

14. The method of claim 13, wherein heating the heart tissue includes generating heat using one of an ultrasound device, a radio frequency device, a resistive heating member, a microwave device, and a laser heating member.

15. The method of claim 13, wherein heating the heart tissue comprises heating from outside of the heart.

16. The method of claim 13, wherein heating the heart tissue comprises heating from inside of the heart.

17. The method of claim 13, further comprising heating the heart tissue to a temperature of about 37°

C. to about 44°

C.

18. The method of claim 13, wherein heating is provided by a heating element, the method further comprising providing a fluid interface between the heating element and the heart tissue.

19. The method of claim 13, further comprising providing a heating element, the heating element carried by a catheter that is inserted through a vessel to the heart.

20. The method of claim 19, wherein the catheter comprises a reperfusion member operable to provide the reperfusing, and the heating element is positioned on the catheter at a location distal of the reperfusion member.