SYSTEMS AND METHODS OF DISCRIMINATING BETWEEN A CONTROL SAMPLE AND A TEST FLUID USING CAPACITANCE

• US 20140151244A1
• Filed: 11/22/2013
• Published: 06/05/2014
• Est. Priority Date: 09/30/2010
• Status: Active Grant

• Current Assignee: LifeScan IP Holdings, LLC
• Original Assignee: Cilag Gmbh International (Johnson & Johnson)
• Inventors: Chatelier, Ronald C., Hodges, Alastair M.
• Granted Patent: US 10,151,724 B2
• Time in Patent Office: Days
• US Class Current: 205/782
• CPC Class Codes: C12Q 1/005 involving specific analytes or enzymes including groups of enzymes, e.g. oxydases; C12Q1/004 takes precedence
• CPC Class Codes: G01N 27/28 Electrolytic cell components
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 33/48707 by electrical means G01N33/49, G01N33/493 take precedence

Abstract

Methods for distinguishing between an aqueous non-blood sample (e.g., a control solution) and a blood sample are provided herein. In one aspect, the method includes using a test strip in which multiple current transients are measured by a meter electrically connected to an electrochemical test strip. The current transients are used to determine if a sample is a blood sample or an aqueous non-blood sample based on characteristics of the sample (e.g., amount of interferent present, reaction kinetics, and/or capacitance). The method can also include calculating a discrimination criteria based upon these characteristics. Various aspects of a system for distinguishing between a blood sample and an aqueous non-blood sample are also provided herein.

Claims

1. A method for calculating a discrimination criteria for programming into a test meter for distinguishing between a blood sample and an aqueous non-blood sample, the method comprising:

(a) calculating a first reference value and a second reference value for a plurality of aqueous non-blood samples,

(b) calculating a third reference value based on the first reference value, the third reference value being proportional to a capacitance index; and

(b) calculating a discrimination criteria based on the second reference value and the third reference value for the plurality of aqueous non-blood samples.

2. The method of claim 1, wherein the first reference value is representative of antioxidant concentration and the second reference value is representative of reaction kinetics.

3. The method of claim 1, wherein the capacitance index comprises a ratio of an average capacitance of electrochemical cells of the same type and the measured capacitance of the electrochemical cell when a sample is introduced.

4. The method of claim 1, wherein the plurality of aqueous non-blood samples comprise a plurality of control solutions.