ANTI-ALLERGIC AGENT

• US 20140154218A1
• Filed: 02/10/2014
• Published: 06/05/2014
• Est. Priority Date: 03/24/2010
• Status: Abandoned Application

• Current Assignee: Morishita Jintan Co., Ltd
• Original Assignee: Morishita Jintan Co., Ltd
• Inventors: KOHNO, Mamiko, KITAMURA, Shinichi, SHOJO, Aiko
• Application Number:
  US14/176,219
• Publication Number:
  US 20140154218A1
• Time in Patent Office: Days
• US Class Current: 424/93.4
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 31/716 Glucans
• CPC Class Codes: A61K 35/745 Bifidobacteria
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: C08B 37/006 Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof

Abstract

According to the present invention, an anti-allergic agent is provided which includes a polysaccharide comprising galactose, glucose and rhamnose as constituents, or includes a microorganism belonging to a genus Bifidobacterium and extracellularly producing the polysaccharide. The anti-allergic agent of the present invention can be used in oral compositions and compositions for external application, and is suitable for use in products such as food products, pharmaceutical products, and cosmetics.

Claims

1. A method for treating allergic disease, comprising:

administering a polysaccharide comprising galactose, glucose and rhamnose as constituents to a subject.

2. The method according to claim 1, wherein the polysaccharide comprises galactose, glucose and rhamnose in a molar ratio of 3-5:

1-3;

1.

3. The method according to claim 2, wherein the polysaccharide comprises the following structure:

4. The method according to claim 1, wherein the polysaccharide is obtained from a microorganism belonging to a genus Bifidobacterium.

5. The method according to claim 4, wherein the microorganism belonging to the genus Bifidobacterium is Bifidobacterium longum.

6. The method according to claim 5, wherein the Bifidobacterium longum is Bifidobacterium longum strain JBL05(NITE BP-82).

7. The method according to claim 1, wherein the polysaccharide is administered as an oral composition.

8. The method according to claim 7, wherein the polysaccharide is administered for suppressing atopic dermatitis or contact dermatitis.

9. The method according to claim 1, wherein the polysaccharide is administered as a composition for external application.

10. The method according to claim 9, wherein the polysaccharide is administered for suppressing atopic dermatitis or contact dermatitis.

11. The method according to claim 2, wherein the polysaccharide is obtained from a microorganism belonging to a genus Bifidobacterium.

12. The method according to claim 3, wherein the polysaccharide is obtained from a microorganism belonging to a genus Bifidobacterium.

13. An anti-allergic agent comprising a microorganism,

the microorganism belonging to a genus Bifidobacterium and producing an extracellular polysaccharide comprising galactose, glucose and rhamnose as constituents.

14. The anti-allergic agent according to claim 13, wherein the polysaccharide comprises galactose, glucose and rhamnose in a molar ratio of 3-5:

1-3;

1.

15. The anti-allergic agent according to claim 14, wherein the polysaccharide comprises the following structure:

16. The anti-allergic agent according to claim 13, wherein the microorganism is Bifidobacterium longum strain JBL05 (NITE BP-82).

17. An oral composition comprising the anti-allergic agent of claim 13.

18. The oral composition according to claim 17, for suppressing atopic dermatitis or contact dermatitis.

19. A method for treating allergic disease, comprising:

administering a microorganism belonging to a genus Bifidobacterium and producing an extracellular polysaccharide comprising galactose, glucose and rhamnose as constituents.

20. The method according to claim 19, wherein the polysaccharide comprises galactose, glucose and rhamnose in a molar ratio of 3-5:

1-3;

1.

21. The method according to claim 20, wherein the polysaccharide comprises the following structure:

22. The method according to claim 19, wherein the microorganism is Bifidobacterium longum strain JBL05 (NITE BP-82).

23. The method according to claim 19, wherein the microorganism is administered as an oral composition.

24. The method according to claim 23, wherein the microorganism is administered for suppressing atopic dermatitis or contact dermatitis.