COMPOSITION FOR PREVENTION AND TREATMENT OF ALLERGIC AND/OR INFLAMMATORY DISEASES

• US 20140154290A1
• Filed: 10/21/2013
• Published: 06/05/2014
• Est. Priority Date: 08/16/2008
• Status: Active Grant

• Current Assignee: Borstel Forschungszentrum, Protectimmun GmbH
• Original Assignee: Borstel Forschungszentrum, Protectimmun GmbH
• Inventors: Kauth, Marion, Bufe, Albrecht, Holst, Otto, Peters, Marcus
• Granted Patent: US 9,375,444 B2
• Time in Patent Office: Days
• US Class Current: 424/282.1
• CPC Class Codes: A61K 2039/55516 Proteins; Peptides
• CPC Class Codes: A61K 2039/55583 Polysaccharides
• CPC Class Codes: A61K 2039/57 characterised by the type of response, e.g. Th1, Th2
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 35/10 Peat; Amber; Turf; Humus
• CPC Class Codes: A61K 35/74 Bacteria therapeutic use of a bacterial protein A61K38/00
• CPC Class Codes: A61K 35/744 Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• CPC Class Codes: A61K 36/899 Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
• CPC Class Codes: A61K 38/168 from plants
• CPC Class Codes: A61K 39/39 characterised by the immunostimulating additives, e.g. chemical adjuvants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 5/50 for increasing or potentiating the activity of insulin

Abstract

A prophylactic antiallergenic composition includes at least one arabinogalactan or arabinogalactan protein. The arabinogalactan or arabinogalactan protein is isolated from a grass or corresponds in its structural arrangement to an arabinogalactan that can be isolated from a grass.

Claims

1. A method of reducing a likelihood of, protecting against or treating allergic diseases or chronic inflammatory diseases, comprising:

administering a prophylactic antiallergenic composition comprising at least one arabinogalactan or arabinogalactan protein into a mammal that is in need of such reduction, protection or treatment,

wherein said at least one arabinogalactan or arabinogalactan protein is isolated from at least one grass or corresponds in its structural arrangement to an arabinogalactan isolatable from at least one grass,

wherein the allergic diseases or chronic inflammatory diseases are selected from the group consisting of IgE-dependent Type I allergic diseases or Type IV allergic diseases, chronic inflammatory skin diseases, and autoimmune diseases.

2. The method according to claim 1, wherein the allergic diseases are selected from the group consisting of IgE-dependent Type I allergic diseases.

3. The method according to claim 1, wherein the method is configured to reduce a likelihood of, protect against or treat one or more selected from the group consisting of hay fever, food allergy, asthma, urticaria, neurodermitis, atopic dermatitis, contact eczema, psoriasis, diabetes type 1 or 2, multiple sclerosis, rheumatoid arthritis, and a disease of the thyroid gland.

4. The method according to claim 1, wherein the method is configured to reduce a likelihood of, protect against or treat one or more selected from the group consisting of hay fever, food allergy, asthma, urticaria, neurodermitis, and atopic dermatitis.

5. The method according to claim 1, wherein the method is configured to reduce a likelihood of, protect against or treat one or more selected from the group consisting of hay fever and asthma.

6. The method according to claim 2, wherein the at least one grass is selected from the group of Meadow Foxtail (Alopecurus pratensis), timothy grass and timothy grass pollen (Phleum pratense L), Cock'"'"'s Foot (Dactyhs glomerata), Yorkshire Fog (Holcus lannatus), English Raygrass (Lolium perenne), Smooth Meadow grass (Poa pratense), Rye (Secale cereale) or grasses from related species or a mixture thereof.

7. The method according to claim 1, wherein the composition comprises an arabinogalactan selected from the group consisting of compounds of the structure shown in FIG. 1.

8. The method according to claim 1, wherein the composition comprises at least one further active ingredient selected from the group of naturally occurring, isolated bacteria of the genus Lactococcus or fragments of said bacteria.

10. The method according to claim 1, wherein the composition comprises at least one further active ingredient comprising humic acid.

11. The method according to claim 1, wherein the composition is a pharmaceutical composition in form of an aerosol, aqueous solution, suspension, lyophilisate, or powder for nasal or inhalative application.

12. The method according to claim 1, wherein the composition is in form for nasal or inhalative administration.

13. The method according to claim 1, wherein the method is suitable for application for an infant (baby) or a pregnant, which due to a positive family anamnesis has an increased risk to develop any allergic disease or chronic inflammatory disease or which shows a first sign of such a disease.

14. The method according to claim 1, wherein the method is configured to provide a prophylactic antiallergenic effect such that said composition is administered before any onset of an allergic disease or an chronic inflammatory disease.

15. The method according to claim 1, wherein the method is suitable for application to a pregnant woman such that said reduction, protection or treatment of an infant will be obtained by the application of the composition to the pregnant mother.

16. The method according to claim 1, wherein the method is suitable for application to an infant.

17. The method according to claim 1, wherein the composition is administered to a child directly after birth thereof.

18. The method according to claim 1, wherein the method is suitable for application to a child during the first years of the child'"'"'s life.

19. The method according to claim 1, wherein the method is suitable for application to a child during the first years of the child'"'"'s life up to 8-10 years.

20. The method according to claim 1, wherein the method is suitable for application to a child within the first five years of the child'"'"'s life.

21. The method according to claim 1, wherein the method is suitable for application to a child within the first two years of the child'"'"'s life.

9. The method according to claim 9, wherein the bacteria are selected from Lactococcus lactis.