PRESERVATION OF THE NEUROMUSCULAR JUNCTION (NMJ) AFTER TRAUMATIC NERVE INJURY
First Claim
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1. A method of treating nerve injury in an individual, comprising:
- providing a composition comprising one or more of the following;
agrin, an inhibitor of the matrix metalloproteinase 3 (MMP3) signaling pathway, an inhibitor of the WNT signaling pathway, and an inhibitor of the beta-catenin signaling pathway; and
administering a therapeutically effective dosage of the composition to the individual.
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Abstract
The invention relates to treatment and/or prevention of nerve injury. In one embodiment, the present invention provides a method of preserving the neuromuscular junction (NMJ) in an individual by administering a therapeutically effective dosage of a composition comprising an inhibitor of Wnt3a, and an inhibitor of MMP3 to the individual. In another embodiment, the present invention provides a method of stabilizing NMJ after nerve injury by inhibiting the WNT and beta-catenin signaling pathway and preserving agrin.
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Citations
29 Claims
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1. A method of treating nerve injury in an individual, comprising:
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providing a composition comprising one or more of the following;
agrin, an inhibitor of the matrix metalloproteinase 3 (MMP3) signaling pathway, an inhibitor of the WNT signaling pathway, and an inhibitor of the beta-catenin signaling pathway; andadministering a therapeutically effective dosage of the composition to the individual. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A composition comprising:
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a therapeutically effective dosage of a composition comprising one or more of the following;
agrin, an inhibitor of the matrix metalloproteinase 3 (MMP3) signaling pathway, an inhibitor of the WNT signaling pathway, and an inhibitor of the beta-catenin signaling pathway; anda pharmaceutically acceptable carrier. - View Dependent Claims (18, 19, 20, 21, 22, 23)
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24. A method of preventing nerve injury in an individual, comprising:
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providing a composition comprising one or more of the following;
agrin, an inhibitor of the matrix metalloproteinase 3 (MMP3) signaling pathway, an inhibitor of the WNT signaling pathway, and an inhibitor of the beta-catenin signaling pathway; andadministering a therapeutically effective dosage of the composition to the individual prior to nerve injury. - View Dependent Claims (25)
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26. A method of preserving the motor end plate after nerve injury in a subject, comprising:
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providing a composition comprising MMP3 pathway specific siRNA, WNT pathway specific siRNA, and beta-catenin pathway specific siRNA; and transfecting one or more cells of the subject with the composition. - View Dependent Claims (27, 28, 29)
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Specification