Antimicrobial effects in polymers

• US 20140170238A1
• Filed: 12/17/2013
• Published: 06/19/2014
• Est. Priority Date: 12/18/2012
• Status: Abandoned Application

• Current Assignee: BASF SE
• Original Assignee: BASF SE
• Inventors: Cliff, Nancy Nase, Jaynes, Bingham Scott, Song, Zhiqiang, Gande, Matthew Edward, Guinta, Allison, Feese, Elke
• Application Number:
  US14/108,955
• Publication Number:
  US 20140170238A1
• Time in Patent Office: Days
• US Class Current: 424/618
• CPC Class Codes: C08F 120/34 Esters containing nitrogen , e.g. N,N-dimethylaminoethyl (meth)acrylate
• CPC Class Codes: C08K 2003/0806 Silver
• CPC Class Codes: C08K 3/015 Biocides macromolecular substances as carriers for biocide material A01N25/10
• CPC Class Codes: C08K 5/0058 Biocides; macromolecular substances as carriers for biocide material A01N25/10
• CPC Class Codes: C08L 33/14 of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
• CPC Class Codes: C09D 133/14 of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
• CPC Class Codes: C09D 5/14 Paints containing biocides, e.g. fungicides, insecticides or pesticides C09D5/16 takes precedence
• CPC Class Codes: C09D 7/61 inorganic
• CPC Class Codes: C09D 7/63 organic

Abstract

This application is directed to compositions of particular combinations of antimicrobial components which may be incorporated into a polymeric molding compositions or polymeric coating compositions. The antimicrobial components include a alkylaminoalkyl(meth)acrylate polymer (b) and antimicrobial metal (a) containing components which lead to improved antimicrobial effects. The compositions are of special interest to durable touch surfaces found in hospitals and clinics. The compositions are also suitable for use in biomaterials such as catheters and the like.

Claims

1. An antimicrobial polymeric coating composition or a polymeric molding composition comprising

(a) An antimicrobial metal;

(b) about 0.1 to about 20 wt. % of a first polymer containing a monomer unit of formula (I)

2. The antimicrobial polymeric coating composition or the polymeric molding composition according to claim 1, wherein the first polymer (b) is a homopolymer and formed from tert-butylaminoethyl(meth)acrylate (tBAEMA).

3. The antimicrobial polymeric coating composition or the polymeric molding composition according to claim 1 wherein the antimicrobial metal of component (a) is selected from the group consisting of zinc, copper, elemental silver, colloidal silver and, silver compounds selected from group consisting of silver nitrate, silver citrate, silver sulfadiazine, silver acetate, silver sulphate, silver chloride, silver oxide, silver complexes;

silver metal-containing zeolites, silver metal-containing glasses and silver-silica composites.

4. The antimicrobial polymeric coating or the polymeric molding composition according to claim 3, wherein the antimicrobial metal of component (a) is selected from elemental silver, colloidal silver and silver compounds selected from the group consisting of silver nitrate, silver citrate, silver sulfadiazine, silver acetate, silver sulphate, silver chloride, silver oxide, silver complexes;

silver metal-containing zeolites, silver metal-containing glasses and silver-silica composites.

5. The antimicrobial polymeric coating composition or the polymeric molding composition according to claim 1, wherein the first polymer of component (b) is a co-polymer formed from the monomer unit of formula (I), which monomer unit of formula (I) comprises about 30 wt. % to about 98 wt. % of the total weight of the co-polymer.

6. The antimicrobial polymeric coating composition or the polymeric molding composition according to claim 4,

wherein the silver

if in the neutral state (elemental silver for example), the weight will range from about 0.05 wt. % to about 10 wt. %;

if in the ionic state (for example Ag⁺, Zn⁺², Cu⁺¹ or Cu⁺²), the wt. % will range from about 0.005 wt. % to about 1 wt. % and the basis is the total weight of the polymer (c) in the composition.

7. The antimicrobial polymeric coating composition or the polymeric molding composition according to claim 1, wherein the first polymer (b) has a weight average molecular weight ranging from about 500 to about 2,000,000 g/mole.

8. The antimicrobial polymeric coating composition or the polymeric molding composition according to claim 1, wherein

if the antimicrobial metal (a) is in ionic state the weight ratio of (b) to (a) will range from about 100 to about 1,

and

if the antimicrobial metal (a) is in the neutral form, the weight ratio of (b) to (a) will range from about 100 to about 10.

9. The antimicrobial polymeric coating composition or the polymeric molding composition according to claim 8, wherein the antimicrobial metal is silver in ionic form and the weight ratio of (b) to (a) will range from about 30 to 15 to 1.

10. The antimicrobial polymeric coating composition or the polymeric molding composition according to claim 1 wherein the composition is a coating composition.

11. The antimicrobial polymer coating composition or polymeric molding composition according to claim 1, wherein the composition is a molding composition.

12. The coating composition of claim 9, wherein (c) is a film forming polymer which is a thermoset or crosslinked polymer.

13. The molding composition according to claim 11 wherein (c) is a thermoplastic and selected from the group of polymers consisting of polysiloxane, siliconE rubber, polyolefins, polyvinylchloride, polymethylmethacrylate, polyesters, polytetrafluoroethylene, polyamides, natural rubbers, polyacetal, polysulfones, polyurethanes, thermoplastic polyurethanes (TPU), polyethers, styrene/acrylic resins and polycarbonates.

14. The coating composition according to claim 10, wherein (c) is a film forming polymer selected from the group consisting of acrylic resin stoving, lacquers or thermosetting resins including acrylic/melamine systems, polyester lacquers, alkyd resin lacquers, lacquers based on alkyd/melamine resins, alkyd/acrylic/melamine resins, acid-catalyzed baked finishes, non-acid catalyzed thermoset resins such as epoxy, epoxy-polyester, vinyl, alkyd, acrylic and polyester resins, optionally modified with silicon, isocyanates or isocyanurates, UV-cured coating systems using unsaturated acrylic resins, polyurethane acrylates, epoxy acrylates, polyester acrylates, unsaturated polyester/styrene resins and silyl acrylates.

15. The antimicrobial polymeric coating composition or polymer molding composition according to any of the preceding claims, wherein the component (c) a film-forming polymer or a thermoplastic polymer and (c) ranges from at least 30 to about 98 wt. % and

the weight % basis of (c) is the total weight of the solids in the polymeric coating composition or the polymeric molding composition.

16. The antimicrobial polymer coating composition or polymeric molding composition according to claim 1, which includes about 0.1 to about 30 wt. % component (d) of formula (II)

17. The antimicrobial polymer coating composition or polymeric molding composition according to claim 15, wherein the component (d) is of formula (III) below.

18. The antimicrobial polymer coating composition or polymeric molding composition according to claim 16, wherein the component (d) is

19. A method of improving the antimicrobial effectiveness of a polymeric coating composition or a polymeric molding composition by

combining (a), (b) (c) and optionally (d) as in claim 1.

20. A masterbatch comprising:

an antimicrobial metal in ionic form (a) and (b) a homopolymer of tBAEMA and (c) a thermoplastic polymer,

wherein the wt. ratio of (b) to (a) when (a) is about 40 to 1, wherein and (c) the thermoplastic makes up about 10 to about 90 wt. % and the wt. % is based on the total weight of the masterbatch.