Method to Determine Distribution of a Material by an Infused Magnetic Resonance Image Contrast Agent
First Claim
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1. A method of determining a selected set of parameters for a therapy on a subject, comprising:
- selecting a material to provide to the subject for the therapy;
accessing a database of predetermined parameters related to a proxy material;
executing instructions with a processor to determine infusion parameters to achieve a selected volume of efficacy in the subject of the selected material; and
outputting the determined infusion parameters for performing the therapy on the subject.
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Abstract
A contrast agent can be infused into a subject and a determination can be made of a VOD and/or a concentration gradient of the contrast agent in the VOD. The contrast agent can be infused in the subject using selected parameters. A correlation to a selected material can be made to determine parameters for infusion the selected material.
121 Citations
20 Claims
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1. A method of determining a selected set of parameters for a therapy on a subject, comprising:
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selecting a material to provide to the subject for the therapy; accessing a database of predetermined parameters related to a proxy material; executing instructions with a processor to determine infusion parameters to achieve a selected volume of efficacy in the subject of the selected material; and outputting the determined infusion parameters for performing the therapy on the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of determining a selected set of parameters for a therapy on a subject, comprising:
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selecting a material to provide to the subject for the therapy; accessing a database of predetermined correlations of parameters relating a proxy material to the selected material; analyzing proxy material image data of the subject after having infused in the subject the proxy material to determine a proxy volume of distribution and a proxy concentration gradient within the proxy volume of distribution; executing instructions with a processor to determine a therapy infusion parameter for infusion of the selected material to achieve a volume of efficacy in the subject of the selected material based on a proxy infusion parameter; and outputting the determined therapy infusion parameter. - View Dependent Claims (12, 13, 14, 15, 16, 17)
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18. A system for determining a selected set of parameters for a therapy on a subject, comprising:
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a memory system that stores a database of predetermined correlations of parameters relating a proxy material to a selected material to provide to the subject for the therapy; a processor configured to execute instructions to; analyze proxy material image data of the subject after having infused in the subject the proxy material to determine a proxy volume of distribution and a proxy concentration gradient within the proxy volume of distribution, access the memory system to recall a correlation between the proxy material and the selected material, and determine a therapy infusion parameter for infusion of the selected material to achieve a volume of efficacy in the subject of the selected material based on a proxy infusion parameter; and a display device configured to display the determined therapy infusion parameter. - View Dependent Claims (19, 20)
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Specification