SURFACE TREATMENT PROCESS FOR IMPLANTABLE MEDICAL DEVICE

• US 20140172028A1
• Filed: 07/18/2012
• Published: 06/19/2014
• Est. Priority Date: 07/19/2011
• Status: Abandoned Application

• Current Assignee: Neoss Limited (Neoss)
• Original Assignee: Neoss Limited (Neoss)
• Inventors: Meredith, Neil
• Application Number:
  US14/233,485
• Publication Number:
  US 20140172028A1
• Time in Patent Office: Days
• US Class Current: 606/331
• CPC Class Codes: A61B 17/866 Material or manufacture
• CPC Class Codes: A61C 8/0013 with a surface layer, coating
• CPC Class Codes: A61C 8/0015 being a conversion layer, e.g. oxide layer
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/34 Macromolecular materials

Abstract

A surface treatment process for improving the hydrophilicity of at least part of an implantable medical device. The process comprises applying to the surface of the implantable medical device a solution of a non-ionic substance having at least one polar covalently-bonded group and drying the implantable medical device to form a hydrophilic deposition of the substance on the surface of the implantable medical device.

Claims

1. A surface treatment process for improving the hydrophilicity of at least part of an endosseous implantable medical device, the process comprising:

applying to a surface of the implantable medical device a non-ionic substance having at least one polar covalently-bonded group, whereby to form a stable deposition of the substance on the surface of the implantable medical device, the deposition being capable of increasing the hydrophilicity of the surface upon application of a liquid thereto by attracting polar water molecules contained in the liquid.

2. The surface treatment process of claim 1, wherein the at least one polar covalently-bonded group comprises a polar hydroxyl (—

OH) group.

3. The surface treatment process of claim 1, wherein the substance is a carbohydrate.

4. The surface treatment process of claim 3, wherein the carbohydrate is a sugar or a sugar alcohol.

5. The surface treatment process of claim 4, wherein the sugar is a monosaccharide or a disaccharide.

6. The surface treatment process of claim 5, wherein the sugar is fructose, maltose, dextrose, glucose or sucrose, or a combination thereof.

7. The surface treatment process of claim 4, wherein the sugar alcohol is xylitol.

8. The surface treatment process of claim 1, wherein the non-ionic substance is applied to the surface of the implantable medical device in solution.

9. The surface treatment process of claim 8, wherein the solution is an aqueous solution.

10. The surface treatment process of claim 8, wherein the solution is applied to the implantable medical device by spraying, or by immersing or dipping the device into the solution.

11. The surface treatment process of claim 8, wherein the solution contains between 1% and 20% by weight of the non-ionic substance.

12. The surface treatment process of claim 8, wherein the implantable medical device is dried after application of the non-ionic substance to form the stable deposition of the substance on the surface of the implantable medical device.

13. The surface treatment process of claim 12, wherein the device is dried at a temperature between 30 and 80 degrees centigrade.

14. The surface treatment process of claim 12, wherein the device is dried for between 5 and 20 minutes.

15. The surface treatment process of claim 1, wherein the implantable medical device is composed of metal or metal alloy.

16. The surface treatment process of claim 13, wherein the implantable medical device is composed of titanium.

17. The surface treatment process of claim 13, wherein the implantable medical device is composed of ceramics.

18. The surface treatment process of claim 1, wherein the implantable medical device is a dental implant.

21. An endosseous implantable medical device having a surface deposition of a non-ionic substance having at least one polar covalently-bonded group treated in accordance with the surface treatment process of claim 1.

19. (canceled)

20. An endosseous implantable medical device having a surface deposition of a non-ionic substance having at least one polar covalently-bonded group.

22. (canceled)