METHODS FOR PREPARATION OF MEDICAL DRESSING CONTAINING ANTIMICROBIAL AGENT
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Abstract
A medical dressing containing an antimicrobial agent is disclosed. The medical dressing comprises a layered fabric comprising an inner layer of substantially hydrophilic material, an outer layer of substantially hydrophobic material on both sides of the inner layer; and an antimicrobial agent. The antimicrobial agent may be releasably impregnated into the fabric, coated on said fabric or a combination thereof. The antimicrobial agent may be a biguanide, such as polyhexamethylene biguanide (PHMB). The fabric inner layer material may be substantially a cellulose fiber, preferably substantially rayon, and the fabric outer layer material may be substantially polyester, e.g., a combination of textile matrix grade polyester fiber and amorphous binder grade polyester fiber. The fabric is preferably treated with an aqueous solution of surfactant and PHMB to have about 1500-3500 ppm of extractable PHMB.
23 Citations
46 Claims
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1-36. -36. (canceled)
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37. A method of preparing a medical dressing comprising;
providing a layered fabric consisting essentially of an inner layer of hydrophilic material, and outer layers of hydrophobic material on both sides of the inner layer, and impregnating a biguanide antimicrobial agent into the inner layer. - View Dependent Claims (38, 39)
- 40. A method comprising providing a dressing consisting essentially of an inner layer of hydrophilic material, outer layers of hydrophobic material on both sides of the inner layer, and a biguanide antimicrobial agent, wherein the antimicrobial agent is releasably contained in the inner layer.
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44. A method of preparing a sponge comprising providing layered plies of a substrate consisting essentially of at least one inner layer of hydrophilic material, outer layers of hydrophobic material on both sides of the at least one inner layer, and a biguanide antimicrobial agent releasably contained in the inner layer.
Specification