Osmotic Ablation Device
First Claim
Patent Images
1. A tissue ablation device comprising:
- a balloon catheter, wherein said balloon catheter is comprised of a semipermeable membrane;
wherein said balloon catheter being insufflated with an osmotically active solution.
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Abstract
A tissue ablation device comprising a balloon catheter, or other expandable element, wherein said expandable element is comprised of a semipermeable membrane. The balloon membrane is expanded by an osmotically active solution to contact a vascular endothelium, or other desired tissue, whereupon the resultant osmotic gradient affects a water flux from the vascular endothelium, or other desired tissue, across the semipermeable membrane and towards the osmotically active solution.
6 Citations
33 Claims
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1. A tissue ablation device comprising:
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a balloon catheter, wherein said balloon catheter is comprised of a semipermeable membrane; wherein said balloon catheter being insufflated with an osmotically active solution.
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2. A tissue ablation device comprising:
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an elongated shaft having at least one lumen therethrough, a proximal end portion and distal end portion, the proximal and distal end portions defining a longitudinal axis there between; an expandable element positioned on the distal end of said shaft, with said expandable element defining at least one chamber which is in fluid communication with one or more of the said lumen, and which when expanded is in substantial direct contact with tissue to be ablated; a fluid material injected into said expandable element with said material being osmotically active and generally hyperosmolar relative to body tissue, and said fluid material giving rise to an osmotic pressure gradient which could affect water flux from body tissue to fluid material; a semipermeable membrane comprising a portion or the entirety of said expandable element, with said membrane permeable to water and impermeable to the osmotically active agent in said fluid material, such that upon substantial direct contact with the tissue to be ablated, said membrane promotes an osmotically driven water flux from tissue, through said membrane, and into said chamber; - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method for osmotically induced destruction of body tissue, said method comprising:
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advancing an elongated catheter into said tissue, wherein said catheter has an expandable element at the distal end comprised in part or in whole of a semipermeable membrane; instillation of an osmotically active liquid material into said expandable element and bringing said expandable element into substantial contact with said tissue; affecting a water flux from said tissue, through said semipermeable membrane, and into chamber defined by said expandable element; wherein the osmotically driven water flux results in tissue desiccation and destruction; - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A method for body tissue sclerosis wherein sclerosis is achieved without direct contact of the sclerosant and said body tissue.
Specification