Tailored Aliphatic Polyesters for Stent Coatings

• US 20140186417A1
• Filed: 02/20/2014
• Published: 07/03/2014
• Est. Priority Date: 07/14/2006
• Status: Active Grant

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Trollsas, O. Mikael, Kleiner, Lothar W., Hossainy, Syed F.A.
• Granted Patent: US 9,067,002 B2
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

An aliphatic polyester polymer for stent coating is described.

Claims

1. A coating on a medical device, comprising a phosphorylcholine (PC) functionalized aliphatic absorbable polymer

wherein the aliphatic absorbable polymer comprises poly glycerol sebacate.

4. The coating of claim 1, wherein the PC functionalized aliphatic polyester forms a thin topcoat on top of a matrix layer comprising the aliphatic polyester.

5. The coating of claim 1, wherein the PC functionalized aliphatic polyester forms a thin topcoat on top of a pure drug layer that is formed on a primer layer or bare metal stent surface.

9. The coating of claim 1, formed on a bare metal stent or an absorbable stent.

10. The coating of claim 1, further comprises a bioactive agent.

11. The coating of claim 10, wherein the bioactive agent is paclitaxel, docetaxel, estradiol, 17-beta-estradiol, nitric oxide donors, super oxide dismutases, super oxide dismutase mimics, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), tacrolimus, dexamethasone, dexamethasone acetate, rapamycin, rapamycin derivatives, 40-O-(2-hydroxy)ethyl-rapamycin (everolimus), 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, 40-O-tetrazole-rapamycin, 40-epi-(N1-tetrazolyl)-rapamycin (ABT-578), γ

-hiridun, clobetasol, mometasone, pimecrolimus, imatinib mesylate, or midostaurin, or a prodrug of these, a co-drug of these, or a combination of these.

12. The coating of claim 1, wherein the medical device is a stent.

13. The coating of claim 1, wherein the medical device is a bioabsorbable stent.

14. The coating of claim 1, wherein the PC functionalized aliphatic absorbable polymer comprises at least one PC moiety(ies) within the backbone of the polymer or as a pendant group off the polymer backbone.

16. A method of treating or ameliorating a medical condition in a ant, comprising implanting in the patient a medical device comprising a coating according to claim 1.

17. A method of treating or ameliorating a medical condition in a ant, comprising implanting in the patient a medical device comprising a coating according to claim 11.

18. The coating of claim 10, wherein the bioactive agent is paclitaxel, docetaxel, estradiol, 17-beta-estradiol, a nitric oxide donor, a super oxide dismutase, 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (4-amino-TEMPO), tacrolimus, dexamethasone, dexamethasone acetate, rapamycin, 40-O-(2-hydroxy)ethyl-rapamycin (everolimus), 40-O-(3-hydroxy)-propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, 40-O-tetrazole-rapamycin, 40-epi-(N1-tetrazolyl)-rapamycin (ABT-578), γ

-hiridun, clobetasol, mometasone, pimecrolimus, imatinib mesylate, midostaurin, or a combination of these.

19. A method of treating or ameliorating a medical condition in a patient, comprising implanting in the patient a medical device comprising a coating according to claim 18.

20. A medical device comprising a coating according to claim 1.

21. A medical device comprising a coating according to claim 4.

22. A medical device comprising a coating according to claim 5.

23. A medical device comprising a coating according to claim 9.

24. A medical device comprising a coating according to claim 10.

25. A medical device comprising a coating according to claim 11.

26. A medical device comprising a coating according to claim 18.

2. (canceled)

3. (canceled)

6. (canceled)

7. (canceled)

8. (canceled)

15. (canceled)