COMPOSITIONS AND METHODS FOR FORMING AND STRENGTHENING BONE

• US 20140186459A1
• Filed: 10/22/2013
• Published: 07/03/2014
• Est. Priority Date: 03/30/1998
• Status: Active Grant

• Current Assignee: Marfly 2, LP
• Original Assignee: Marfly 2, LP
• Inventors: Marchosky, Jose Alexander
• Granted Patent: US 9,254,301 B2
• Time in Patent Office: Days
• US Class Current: 424/549
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/722 Chitin, chitosan
• CPC Class Codes: A61K 31/728 Hyaluronic acid
• CPC Class Codes: A61K 31/734 Alginic acid
• CPC Class Codes: A61K 35/32 Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
• CPC Class Codes: A61K 38/1866 Vascular endothelial growth factor [VEGF]
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

Compositions are provided which stimulate bone growth. Also provided are methods for utilizing the compositions for filling in bone defects, promoting rapid fusion of bone fractures, grafts, and bone-prostheses, and promoting strengthening of osteoporotic bones.

Claims

1-45. -45. (canceled)

46. A composition for promoting the growth and strengthening of bone comprising a mixture of a chitosan or chitosan derivative, cancellous bone, and demineralized bone matrix.

47. A composition of claim 46, wherein said composition comprises demineralized bone matrix is present at 10%;

the cancellous bone is present at 10%; and

the gel material is a 3% (w/v)of chitosan or chitosan derivative.

48. A composition of claim 46, wherein said composition comprises demineralized bone matrix is present at 20%;

the cancellous bone is present at 20%; and

the gel material is a 3% (w/v)of chitosan or chitosan derivative.

49. A composition of claim 46, wherein said composition comprises demineralized bone matrix is present at 10%;

the cancellous bone is present at 30%; and

the gel material is a 3% (w/v)of chitosan or chitosan derivative.

57. A method of inducing bone formation in a vertebrate comprising applying a composition of claim 46 to a site in the vertebrate where bone formation is desired.

58. The method of claim 57, wherein the site is the junction of an allograft or autograft and a bone.

59. The method of claim 57, wherein the site is the junction of a bone and a bone prosthesis.

60. The method of claim 57, wherein the site is a fracture.

50. A composition for promoting the growth and strengthening of bone comprising a mixture of alginate, calcium, cancellous bone, and demineralized bone matrix.

51. A composition of claim 50, wherein said composition comprises demineralized bone matrix is present at 10%;

the cancellous bone is present at 30%; and

the gel material is a 3% (w/v)of alginate with or without calcium.

52. A composition of claim 50, wherein said composition comprises demineralized bone matrix is present at 20%;

the cancellous bone is present at 20%; and

the gel material is a 3% (w/v)of alginate with or without calcium.

53. A composition of claim 50, wherein said composition comprises demineralized bone matrix is present at 10%;

the cancellous bone is present at 10%; and

the gel material is a 3% (w/v)of alginate with or without calcium.

54-56. -56. (canceled)

61-64. -64. (canceled)

65. A composition, comprising:

(a) one or more angiogenesis-stimulating materials;

(b) an osteoinductive material;

(c) a scaffolding material; and

(d) a gel material.