METHODS AND DEVICES FOR COMPOUND DELIVERY

• US 20140190496A1
• Filed: 11/27/2013
• Published: 07/10/2014
• Est. Priority Date: 11/28/2012
• Status: Abandoned Application

• Current Assignee: Fontem Holdings 1 BV (Imperial Tobacco Group PLC)
• Original Assignee: e-Nicotine Technology, Inc (Imperial Tobacco Group PLC)
• Inventors: Wensley, Martin, Hufford, Michael, Williams, Jeffrey, Lloyd, Peter
• Application Number:
  US14/092,405
• Publication Number:
  US 20140190496A1
• Time in Patent Office: Days
• US Class Current: 131/273
• CPC Class Codes: A24B 15/167 in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
• CPC Class Codes: A24F 40/10 Devices using liquid inhalable precursors
• CPC Class Codes: A24F 40/485 Valves; Apertures
• CPC Class Codes: A61M 11/001 Particle size control
• CPC Class Codes: A61M 11/002 by flow deviation causing inertial separation of transported particles
• CPC Class Codes: A61M 11/042 electrical
• CPC Class Codes: A61M 15/002 with air flow regulating means
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/0066 with means for varying the dose size
• CPC Class Codes: A61M 15/0083 Timers
• CPC Class Codes: A61M 15/06 Inhaling appliances shaped like cigars, cigarettes or pipes
• CPC Class Codes: A61M 2016/0015 inhalation detectors
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3561 local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/3592 using telemetric means, e.g. radio or optical transmission
• CPC Class Codes: A61M 2205/3653 by Joule effect, i.e. electric resistance
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/8206 : battery-operated
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Provided herein are methods, devices, systems, and computer readable medium for delivering one or more compounds to a subject. Also described herein are methods, devices, systems, and computer readable medium for transitioning a smoker to an electronic nicotine delivery device and for smoking or nicotine cessation.

Claims

1. A condensation aerosol generating device for generating a condensation aerosol of a liquid formulation, the device comprising:

a. a reservoir comprising a liquid formulation; and

b. a passageway comprising a heater element, wherein the reservoir is in fluid communication with the heater element, wherein the heater element is capable of vaporizing the liquid formulation when the liquid formulation is delivered onto the heater element, and wherein a flow of air through the passageway condenses the vaporized liquid formulation into particles having a mass median aerodynamic diameter (MMAD) of from about 1 μ

m to about 5 μ

m.

2. The device of claim 1, wherein the device is configured to produce an internal air resistance of from about 0.08 to about 0.12 sqrt (cm-H₂O)/LPM.

3. The device of claim 1, wherein the passageway comprises an upstream opening and a downstream opening, wherein the upstream opening comprises an inlet for the air and the downstream opening serves as an outlet for air.

4. The device of claim 3, wherein the heater element is located within the passageway between the upstream and downstream openings.

5. The device of claim 3, wherein the reservoir is located within the passageway between the upstream and downstream openings.

6. The device of claim 3, further comprising an air flow regulator located in the passageway.

7. The device of claim 6, further comprising a second passageway, wherein the air flow regulator is capable of directing air through the second passageway in response to a pressure drop across the air flow regulator.

9. The device of claim 1, wherein the heater element comprises a wire coil.

10. The device of claim 1, further comprising a capillary in fluid communication with the reservoir.

11. The device of claim 10, wherein the capillary is in fluid communication with the heater element.

12. The device of claim 10, wherein the capillary comprises a heatable region.

13. The device of claim 12, further comprising a check valve located in the capillary between the heatable region and the reservoir.

14. The device of claim 1, further comprising a controller, wherein the controller comprises a non-transitory computer readable medium comprising one or more algorithms, wherein the one or more algorithms regulate dosing or a delivery schedule of the condensation aerosol of the liquid formulation.

15. The device of claim 14, further comprising an interface for communicating with the controller.

16. The device of claim 14, wherein the controller is removably attached to the passageway and the reservoir.

17. The device of claim 14, wherein the controller is capable of communicating with one or more electronic devices.

18. The device of claim 1, wherein the liquid formulation comprises a flavoring.

8. The device of claim 8, wherein the air flow regulator comprises one or more gas control valves.

19. A condensation aerosol generating device for generating a condensation aerosol of a liquid formulation, the device comprising:

a. a passageway comprising a heater element; and

b. a reservoir comprising the liquid formulation, wherein the reservoir is in fluid communication with the heater element, wherein the heater element is capable of vaporizing the liquid formulation when the liquid formulation is delivered onto the heater element, and wherein a flow of air through the device delivers the condensation aerosol of the liquid formulation to the deep lung of a subject using the device.

20. The device of claim 19, wherein the device permits a flow resistance of from about 0.08 to about 0.12 sqrt (cm-H₂O)/LPM.

21. The device of claim 19, wherein the passageway comprises an upstream opening and a downstream opening, wherein the upstream opening comprises an inlet for the air and the downstream opening serves as an outlet for the air, and wherein the heater element is located in the passageway between the upstream and downstream openings.

22. The device of claim 19, wherein the reservoir is located within the passageway between the upstream and downstream openings.

23. The device of claim 19, further comprising an air flow regulator located in the passageway.

24. The device of claim 23, further comprising a second passageway, wherein the air flow regulator is capable of directing the air through the second passageway in response to a pressure drop across the air flow regulator.

25. The device of claim 24, wherein the air flow regulator comprises one or more gas control valves.

26. The device of claim 19, wherein the heater element comprises a wire coil.

27. The device of claim 19, further comprising a capillary in fluid communication with the reservoir.

28. The device of claim 27, wherein the capillary is in fluid communication with the heater element.

29. The device of claim 27, wherein the capillary comprises a heatable region.

30. The device of claim 19, further comprising a controller, wherein the controller comprises a non-transitory computer readable medium comprising one or more algorithms wherein the one or more algorithms regulate dosing or a delivery schedule of the condensation aerosol of the liquid formulation.

31. The device of claim 30, further comprising an interface for communicating with the controller.

32. The device of claim 30, wherein the controller is removably attached to the passageway and the reservoir.

33. The device of claim 30, wherein the controller is capable of communicating with one or more electronic devices.

34. The device of claim 19, wherein the liquid formulation comprises a flavoring.

35. A method of administering a condensation aerosol to a deep lung of a subject, the method comprising:

a. generating a condensation aerosol, wherein the generating comprises vaporizing a liquid formulation delivered onto a heater element, wherein the heater element is located in a passageway of a condensation aerosol generating device, wherein the condensation aerosol has an MMAD of from about 1 μ

m to about 5 μ

m; and

b. flowing a gas through the condensation aerosol generating device to deliver the condensation aerosol to a deep lung of a subject using the device.

36. The method of claim 35, wherein the condensation aerosol generating device is configured to produce an internal air resistance of from about 0.08 to about 0.12 sqrt (cm-H₂O)/LPM.

37. The method of claim 35, wherein the passageway comprises an upstream opening and a downstream opening, wherein the upstream opening comprises an inlet for the air and the downstream opening serves as an outlet for air.

38. The method of claim 37, wherein the heater element is located within the passageway between the upstream and downstream openings.

39. The method of claim 37, wherein the condensation aerosol generating device further comprises a reservoir located within the passageway between the upstream and downstream openings.

40. The method of claim 35, wherein the condensation aerosol generating device further comprises an air flow regulator located in the passageway.

41. The method of claim 40, wherein the condensation aerosol generating device further comprises a second passageway, wherein the air flow regulator is capable of directing air through the second passageway in response to a pressure drop across the air flow regulator.

42. The method of claim 41, wherein the air flow regulator comprises one or more gas control valves.

43. The method of claim 37, wherein the heater element comprises a wire coil.

44. The method of claim 37, wherein the condensation aerosol generating device further comprises a capillary in fluid communication with the reservoir.

45. The method of claim 44, wherein the capillary is in fluid communication with the heater element.

46. The method of claim 44, wherein the capillary comprises a heatable region.

47. The method of claim 46, wherein the condensation aerosol generating device further comprises a check valve located in the capillary between the heatable region and the reservoir.

48. The method of claim 35, wherein the condensation aerosol generating device further comprises a controller, wherein the controller comprises a non-transitory computer readable medium comprising one or more algorithms, wherein the one or more algorithms regulate dosing or a delivery schedule of the condensation aerosol of the liquid formulation.

49. The method of claim 48, wherein the condensation aerosol generating device further comprises an interface for communicating with the controller.

50. The method of claim 48, wherein the controller is removably attached to the passageway and the reservoir.

51. The method of claim 48, wherein the controller is capable of communicating with one or more electronic devices.

52. A condensation aerosol generating device for generating a condensation aerosol of a liquid formulation, the device comprising:

a passageway comprising a heater element, an inlet, and an outlet, wherein the heater element is located between the inlet and the outlet of the passageway, wherein the passageway is adapted to produce a condensation aerosol from a liquid formulation delivered onto the heater element, and wherein the device is configured to produce an internal air resistance that is no greater than that of a cigarette.

53. The device of claim 52, wherein the internal air resistance is at most 0.20 sqrt (cm-H₂O)/LPM.

54. The device of claim 52, wherein the internal air resistance is from about 0.08 to about 0.12 sqrt (cm-H₂O)/LPM.

55. The device of claim 52, further comprising a reservoir in fluid communication with the heater element.

56. The device of claim 52, wherein the device further comprises an air flow regulator located in the passageway.

57. The device of claim 56, further comprising a second passageway, wherein the air flow regulator is capable of directing air through the second passageway in response to a pressure drop across the air flow regulator.

58. The device of claim 57, wherein the air flow regulator comprises one or more gas control valves.

59. The device of claim 52, wherein the heater element comprises a wire coil.

60. The device of claim 52, wherein the device is configured to detect inhalation from a user.

61. The device of claim 60, wherein the device is further configured to produce the condensation aerosol within 1000 milliseconds from the detection of inhalation from the user.

62. The device of claim 61, wherein the condensation aerosol is present in the first third of the volume of air inhaled by the user.

63. The device of claim 52, wherein the liquid formulation comprises nicotine.