ANALYZERS WITH TIME VARIATION BASED ON COLOR-CODED SPATIAL MODULATION

• US 20140192359A1
• Filed: 01/14/2014
• Published: 07/10/2014
• Est. Priority Date: 02/01/2008
• Status: Active Grant

• Current Assignee: Xerox Corporation (Xerox Holdings Corp.)
• Original Assignee: Palo Alto Research Center, Inc. (Xerox Holdings Corp.)
• Inventors: Martini, Joerg, Kiesel, Peter, Huck, Malte, Bern, Marshall W., Johnson, Noble M., Bassler, Michael, Beck, Markus
• Granted Patent: US 9,341,562 B2
• Time in Patent Office: Days
• US Class Current: 356/417
• CPC Class Codes: G01J 2003/1213 Filters in general, e.g. dichroic, band
• CPC Class Codes: G01J 3/26 using multiple reflection, e.g. Fabry-Perot interferometer, variable interference filters
• CPC Class Codes: G01J 3/28 Investigating the spectrum using colour filters G01J3/51
• CPC Class Codes: G01J 3/2803 using photoelectric array detector
• CPC Class Codes: G01N 2021/0346 Capillary cells; Microcells
• CPC Class Codes: G01N 21/05 Flow-through cuvettes G01N21/09 takes precedence; handling fluid samples G01N1/10
• CPC Class Codes: G01N 21/25 Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• CPC Class Codes: G01N 21/255 Details, e.g. use of specially adapted sources, lighting or optical systems
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters
• CPC Class Codes: G02B 21/16 adapted for ultraviolet illumination ; Fluorescence microscopes G02B21/0076 takes precedence
• CPC Class Codes: G02B 27/46 Systems using spatial filters

Abstract

A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences. The filter arrangement, in a practical commercial embodiment, can be manufactured to be disposable, and used in a point-of-care device for use practically anywhere, at low cost, and can also be implemented in an in-line monitoring system.

Claims

1. An apparatus, comprising:

a structure that provides for relative motion between an object and a filter assembly, wherein the object is an area within a larger object; and

an encoding component that includes the filter assembly, the filter assembly configured to receive light emanating from objects in the structure;

wherein the filter assembly is adapted to provide output light in response to input light that is within an application'"'"'s range of photon energies and that is emanating from the object moving relative to the filter assembly;

wherein the filter assembly includes a set of positions, each having a respective transmission function within the range;

wherein the object'"'"'s relative motion with respect to the filter assembly include at least two segments from which respective positions in the set receive light emanating from the object; and

wherein the filter assembly includes a longitudinal sequence of filter regions, the filter regions including first regions of a first filter type and second regions of a second filter type, the first and second filter types transmitting respective first and second spectral ranges of light, the first and second spectral ranges being sufficiently different from each other that the difference causes time variation in the output light while the object travels through the respective segments.

5. The apparatus of claim 1, further comprising:

a source of excitation light configured to illuminate the object and to stimulate the emanating light from the object;

a detector disposed to receive the output light from the filter assembly, the detector adapted to provide a detector output based on the received light; and

a blocking filter disposed between the detector and the flow channel, the blocking filter configured to block the excitation light and to transmit at least a portion of the first and second spectral ranges of light.

13. The apparatus of claim 1,

wherein the filter assembly further includes opaque regions, at least one opaque region being disposed between two adjacent first regions and at least another opaque region being disposed between two adjacent second regions;

and

wherein the opaque regions are arranged in an alternating fashion with at least some of the first regions.

14. The apparatus of claim 1, wherein at least one of the first regions at least partially overlaps at least one of the second regions to provide a broadened filter region, the broadened filter region transmitting both light of the first spectral range and light of the second spectral range.

16. The apparatus of claim 1, wherein the longitudinal sequence of filter regions has a longitudinal length L, wherein the first regions collectively form a first subpattern having a first longitudinal length LA, wherein the second regions collectively form a second subpattern having a second longitudinal length LB, and wherein the first and second subpatterns at least partially overlap such that L<

LA+LB.

17. The apparatus of claim 1, wherein the longitudinal sequence of filter regions has a longitudinal length L, wherein the first regions collectively form a first subpattern having a first longitudinal length LA, wherein the second regions collectively form a second subpattern having a second longitudinal length LB, and wherein the first and second subpatterns do not substantially overlap such that L≧

LA+LB.

2-4. -4. (canceled)

6. The apparatus of claim, further comprising:

a detector disposed to receive the output light from the filter assembly, the detector adapted to provide a detector output based on the received light.

7. The apparatus of claim 6, further comprising:

a signal processing unit coupled to the detector to receive the detector output and to provide a system output based on the detector output, the system output providing one or more characteristics of the object.

8-12. -12. (canceled)

15. (canceled)

18. A method, comprising:

exciting at least one object such that the object emanates light, the object being an area within a larger object;

causing relative motion between the object and the filter assembly such that light emanating from the excited object is sequentially filtered through a longitudinal sequence of filter regions to provide a filtered output light, the longitudinal sequence of filter regions including first regions of a first filter type and second regions of a second filter type, the first and second filter types transmitting respective first and second spectral ranges of light, the first and second spectral ranges of the respective filter regions being sufficiently different from each other that the difference causes a time variation in the filtered output light;

detecting the filtered output light and providing a time-varying detector output as a function of the detected light; and

analyzing the time-varying detector output to provide one or more characteristics of the object.

19. The method of claim 18, wherein the analyzing includes evaluating frequency content of the time-varying detector output to measure frequency component magnitudes at a plurality of frequencies, and to provide the one or more characteristics of the object based on the measured frequency component magnitudes.

20. The method of claim 19, wherein the analyzing includes comparing at least a first and second one of the measured frequency component magnitudes.

21. The method of claim 18, wherein the analyzing includes identifying one or more peaks in a frequency spectrum of the time-varying detector output.

22. The method of claim 21, wherein identifying one or more peaks includes identifying a dominant peak in the frequency spectrum, and measuring coordinates of the dominant peak, including a first frequency of the dominant peak and a first frequency component magnitude of the dominant peak.

27. The method of claim 18, wherein the analyzing includes correlating the time varying detector output to an additional signal to produce a correlation result.

28. The method of claim 27, wherein the additional signal comprises a template.

29. The method of claim 28, further comprising calculating a derivative with respect to time of the correlation result.

31. The method of claim 27, further comprising distinguishing the object from other objects based on the information.

23-26. -26. (canceled)

30. A method of using a filter arrangement, the method comprising:

during relative movement between an object and the filter arrangement, the object emanating light within an application'"'"'s range of photon energies and transmitting/reflecting at least some of the emanating light through the filter arrangement;

the act of transmitting/reflecting at least some of the emanating light through the filter arrangement producing time variation in the emanating light that includes information about characteristics of the object, wherein the object is a color area within a larger object, the act of transmitting/reflecting including at least one of;

transmitting/reflecting respective portions of the emanating light through respective positions of a filter assembly within the filter arrangement;

two of the positions that are adjacent having respective transmission functions sufficiently different from each other that the difference causes time variation in the emanating light between the respective segments; and

transmitting/reflecting a respective portion of the emanating light through a filter component within the filter arrangement;

the filter component having a combined transmission function in which a set of two or more simpler transmission functions is superimposed;

the set including first and second simpler non-uniform transmission functions, the set being superimposed such that time variation occurs in the emanating light in accordance with superposition of the first and second simpler nonuniform transmission functions.

32. An apparatus comprising:

an encoding component, the encoding component including a filter arrangement that can receive light emanating from objects in response to input light that is within an application'"'"'s range of photon energies and that is emanating from an object during relative motion between the object and the filter arrangement, the filter arrangement providing output light that includes information about one or more characteristics of the object wherein the object is a colored area within a larger object;

the filter arrangement including at least one of;

a filter assembly that includes a set of positions, each having a respective transmission function within the range;

a series of segments of an object'"'"'s relative motion including at least two segments from which respective positions in the set receive light emanating from the object, two of the respective positions that are adjacent having respective transmission functions sufficiently different from each other that the difference causes time variation in the output light while the object travels through the respective segments; and

a filter component that receives input light from a segment of an object and that, within the range, has a combined transmission function in which a set of two or more simpler transmission functions is superimposed;

the set including first and second simpler non-uniform transmission functions, the set being superimposed such that time variation occurs in the output light in accordance with superposition of the first and second simpler non-uniform transmission functions while the object travels through the segment.

33. The apparatus of claim 32 wherein the filter arrangement includes at least one of:

an absorption filter;

an interference-based filter;

a light-transmissive and/or light-reflective filter;

a longitudinal sequence of filters that vary in a periodic,

random, or chirped pattern;

filter elements of two or more colors;

filter elements of two or more gray levels;

overlapping filter elements;

a longitudinal sequence of filter elements that includes

binary, gray level, and color filter elements;

two or more lengthwise extending filter elements;

a radial sequence of filter elements;

two orthogonally striped filter assemblies;

filter assemblies on opposite sides of a fluidic channel; and

a stack-equivalent filter.

34. The apparatus of claim 32, wherein the information comprises color of the object.

35. The apparatus of claim 32, wherein the information comprises differences in color emanating from the object.

36. An article of manufacture, comprising:

a structure, wherein excitation light enters the structure and interacts with an object resulting in emanating light; and

one or more mask arrangements configured to receive at least part of the emanating light and in response, provide encoded emanating light,

wherein the one or more mask arrangements and the channel are further configured so that the encoded emanating light includes time variation resulting from relative movement between the one or more mask arrangements and the object, the time variation including information the object, wherein the object comprises an area within a larger object; and

a photo-sensor configured to receive the encoded emanating light and detect time variation resulting from relative movement between the one or more mask arrangements and the objects, and wherein the photo-sensor is further configured to provide an electrical signal indicating one or more sensed time-varying waveforms.