CONTACT LENSES HAVING TWO-ELECTRODE ELECTROCHEMICAL SENSORS

• US 20140194713A1
• Filed: 09/17/2013
• Published: 07/10/2014
• Est. Priority Date: 08/06/2012
• Status: Abandoned Application

• Current Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Original Assignee: Google Inc. (Alphabet Inc.)
• Inventors: Liu, Zenghe
• Application Number:
  US14/029,281
• Publication Number:
  US 20140194713A1
• Time in Patent Office: Days
• US Class Current: 600/347
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/14507 specially adapted for measuring characteristics of body fluids other than blood devices for taking samples of body liquids A61B10/0045
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/6821 Eye

Abstract

Apparatus, systems and methods employing contact lenses with two-electrode electrochemical sensors are provided. In some aspects, the contact lens includes: a substrate that forms at least part of a body of the contact lens; and a circuit, disposed on or within the substrate, and including a two-electrode electrochemical sensor. The two-electrode electrochemical sensor can include: a working electrode; and a combination reference-counter electrode. The electrochemical sensor can be an amperometric sensor that senses a biological feature of a wearer of the contact lens. The working electrode can generate a signal indicative of the sensed analyte, and the combination reference-counter electrode can pass the signal generated from the working electrode. The signal can be employed to determine the analyte concentration of a solution in contact with the contact lens.

Claims

1. A contact lens, comprising:

a substrate that forms at least part of a body of the contact lens; and

a circuit, disposed on or within the substrate, wherein the circuit comprises a communication component and a two-electrode electrochemical sensor, wherein the communication component comprises an antenna, and wherein the two-electrode electrochemical sensor comprises;

a working electrode; and

a combination reference-counter electrode.

2. The contact lens of claim 1, wherein the working electrode generates a signal indicative of a sensed analyte.

3. The contact lens of claim 2, wherein the combination reference-counter electrode passes the signal generated from the working electrode.

4. The contact lens of claim 1, wherein the working electrode and the combination reference-counter electrode are comprised of a same material.

5. The contact lens of claim 1, wherein the working electrode is comprised of platinum and the combination reference-counter electrode is comprised of a noble metal.

6. The contact lens of claim 1, wherein the combination reference-counter electrode is comprised of at least one of carbon or silver/silver chloride.

7. The contact lens of claim 1, wherein the two-electrode electrochemical sensor comprises a hydrogen peroxide sensor with two platinum electrodes.

8. The contact lens of claim 1, wherein the two-electrode electrochemical sensor is an amperometric sensor.

9. The contact lens of claim 8, wherein the amperometric sensor is a biosensor that senses a level of at least one of glucose, protein, triglycerides, urea or lactate in a body of a wearer of the contact lens.

10. The contact lens of claim 8, wherein the amperometric sensor comprises a working electrode having glucose oxidase deposited on the working electrode.

11. The contact lens of claim 1, wherein the working electrode is smaller than the combination reference-counter electrode.

12. The contact lens of claim 11, wherein a ratio of an area of the combination reference-counter electrode and an area of the working electrode is between 2 and 10000.

13-20. -20. (canceled)