Emboli detection in the brain using a transcranial doppler photoacoustic device capable of vasculature and perfusion measurement
First Claim
1. A device for detecting emboli in the brain comprising, in combination:
- an array of ultrasound transducers;
actuators coupled to the array of ultrasound transducers;
said actuators enabled to alter, skew, move, rotate, or change the position of the transducers;
said actuators enabled to be controlled remotely; and
the array of ultrasound transducers having the ability to learn and send Doppler shifted signals, regarding blood flow from brain and neck vasculatures, to a remote site.
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Accused Products
Abstract
A device, method, and system for detecting emboli in the brain is disclosed. A transcranial Doppler photoacoustic device transmits a first energy to a region of interest at an internal site of a subject to produce an image and blood flow velocities of a region of interest by outputting an optical excitation energy to said region of interest and heating said region, causing a transient thermoelastic expansion and produce a wideband ultrasonic emission. Detectors receive the wideband ultrasonic emission and then generate an image of said region of interest from said wideband ultrasonic emission. A Doppler ultrasound signal will also be deployed to image the region of interest. Doppler presents changes in velocity to map blood flow. Additionally, a dye can be given to visualize the brain vasculature and a perfusion measurement can be made in various regions of the brain along with the transcranial Doppler and the photoacoustic screening. Systems are taught using resultory medical data for better triage within an enhanced stroke ecosystem.
107 Citations
69 Claims
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1. A device for detecting emboli in the brain comprising, in combination:
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an array of ultrasound transducers; actuators coupled to the array of ultrasound transducers; said actuators enabled to alter, skew, move, rotate, or change the position of the transducers; said actuators enabled to be controlled remotely; and the array of ultrasound transducers having the ability to learn and send Doppler shifted signals, regarding blood flow from brain and neck vasculatures, to a remote site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for detecting emboli in the brain and sending the relevant data to a remote site which comprises, in combination:
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configuring an ultrasound array to transmit a beam pattern sufficient to isonate a region of interest at an internal site of a subject; finding, creating, and displaying maps or images of said region of interest; identifying acute occlusion or stenosis in major brain and neck arteries; wirelessly transmitting data identified to a remote site; and wirelessly receiving information about data identified from the remote site at the site of the subject where the device is being used. - View Dependent Claims (16, 17, 18, 19, 20, 21)
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22. A method of configuring an ultrasound array to transmit a beam pattern sufficient to insonate a region of interest at an internal site of a subject, said method comprising, in combination:
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a) providing an array of ultrasound transducer elements; b) outputting a beam pattern from said array of ultrasound transducer elements to insonate a region of interest at an internal site in a body sufficiently large that the beam pattern comprises a multi-beam pattern, insonating multiple receiver elements over a substantially simultaneous period by directing energy produced by said array of ultrasound transducer elements into said region of interest in said body, and adjusting an amplitude of energy output by said array of transducers to cause the beam pattern output to have a generally flat upper pattern and nulling in a grating lobe region; and
,c) introducing a phase shift of the beam pattern output from said array of ultrasound transducer elements, wherein a degree of phase shift increases as a distance increases from a central output area of said array of ultrasound transducer elements. - View Dependent Claims (23)
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24. A method of configuring an ultrasound array to transmit a beam pattern sufficient to insonate a region of interest at an internal site of a subject, said method comprising the steps of:
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a) providing an array of ultrasound transducer elements; b) outputting a beam pattern from said array of ultrasound transducer elements to insonate a region of interest at an internal site in a body sufficiently large that the beam pattern comprises a multi-beam pattern, insonating multiple receiver elements over a substantially simultaneous period by directing energy produced by said array of ultrasound transducer elements into said region of interest in said body, and adjusting an amplitude of energy output by said array of transducers to cause the beam pattern output to have a generally flat upper pattern and nulls in a grating lobe region; and
,c) introducing a phase shift of the beam pattern output from said array of ultrasound transducer elements, wherein a degree of phase shift increases as a distance increases from a central output area of said array of ultrasound transducer elements. - View Dependent Claims (25, 26, 27, 28)
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29. A method for operating an array of ultrasound transducer elements, wherein:
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the element spacing in the array is greater than, equal to or less than a half wavelength of the ultrasound energy produced by the elements, and wherein the array is used differently in transmit and receive modes, comprising; forming a transmit beam from a position external to a region of interest encompassing a plurality of receive beams and initially acquiring a signal by insonating a target region comprising multiple receive beam positions over a substantially simultaneous period; receiving data from the multiple receive beam positions of the array; combining the received data in a processor; locking onto the receive beam and the point(s) producing a peak signal; and correcting for motions in the target region by periodically forming multiple receive beams and re-acquiring the peak signal. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
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- 66. A data reduction and analysis system wherein actuators coupled to ultrasound transducers can be remotely manipulated, over the Internet or radio or land links, with control taking place at a remote site distal from the patient.
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69. A method to detect prostate cancer, comprising, in combination:
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injecting ICN-pSMA molecule to the prostate area which combines with the surface of Prostate Cancer cells, and liberates ICN in the process; insonating the prostate and the adjacent vicinity with energy from a phased array Doppler device; insonating the prostate and the adjacent vicinity with energy from a photoacoustic device; and detecting the spectrum of a plurality of ICN molecules in the region of the Cancer.
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Specification