MEDICAL DEVICE, COMBINATION OF COATING SOLUTIONS, AND METHOD FOR PRODUCING MEDICAL DEVICE
First Claim
Patent Images
1. A medical device having:
- an elastic modulus of 100 kPa or more and 2,000 kPa or less,a water content of 10% by mass or less,a tensile elongation of 50% or more and 3,000% or less, anda dynamic contact angle (advancing angle) relative to a borate buffer of 80°
or less.
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Abstract
Disclosed is a medical device having an elastic modulus of 100 kPa or more and 2,000 kPa or less, a water content of 10% by mass or less, a tensile elongation of 50% or more and 3,000% or less, and a dynamic contact angle (advancing angle) relative to a borate buffer of 80° or less. The present invention can significantly reduce or avoid a phenomenon of adhesion to a surface when contacted with a surface outside or inside the body, which has hitherto been regarded as a problem in a conventional medical device.
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Citations
16 Claims
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1. A medical device having:
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an elastic modulus of 100 kPa or more and 2,000 kPa or less, a water content of 10% by mass or less, a tensile elongation of 50% or more and 3,000% or less, and a dynamic contact angle (advancing angle) relative to a borate buffer of 80°
or less. - View Dependent Claims (2, 3, 4, 5)
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6. A method for producing a medical device in which LbL coating is applied to a base material through n steps in total from a first step of bringing a base material into contact with a first solution containing a first polymer to thereby noncovalently apply the first polymer onto the base material to an nth step (n is an integer of 2 or more) of bringing the base material into contact with an nth solution containing an nth polymer to thereby noncovalently apply the nth polymer onto the base material, thus obtaining the medical device, the method comprising:
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bringing any one (k−
1)th solution (k is an integer of 2 or more and n or less) of the first solution to the nth solution into contact with a quartz resonator sensor for quartz crystal microbalance (QCM), and quickly washing the quartz resonator sensor with pure water, followed by drying and further the measurement of a resonance frequency using the QCM to obtain a measured value Fk-1,subsequently bringing a kth solution into contact with this quartz resonator sensor, and quickly washing the quartz resonator sensor with pure water, followed by drying and further the measurement of a resonance frequency using the QCM to obtain a measured value Fk, and using the (k−
1)th solution and the kth solution in which the Fk−
the Fk-1 is 1,500 or more,wherein a quartz resonator sensor (resonance frequency of 9 MHz, AT-cut, gold electrode) is used as the quartz resonator sensor, and the measurement is performed at a fundamental frequency of 27 MHz at room temperature (about 25°
C.) using the QCM.
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7. A combination of coating solutions for applying LbL coating to a medical device, comprising a first solution to an nth solution,
wherein a coating solution containing a first polymer for noncovalently applying the first polymer onto a base material is used as a first solution, and a coating solution containing a kth polymer for noncovalently applying the kth polymer onto a base material is used as a kth solution (k is an integer of 2 or more and n or less, n is an integer of 2 or more), and when a quartz resonator sensor for quartz crystal microbalance (QCM) is immersed in a first solution at 25° - C. for 30 minutes, and then the quartz resonator sensor is quickly washed with pure water and dried, followed by the measurement of a resonance frequency using the QCM to obtain a measured value F1, and
subsequently, the quartz resonator sensor is immersed in a second solution containing a second polymer at 25°
C. for 30 minutes immersed, and then the quartz resonator sensor is quickly washed with pure water and dried, followed by the measurement of a resonance frequency using the QCM to obtain a measured value F2, andthe measurement to a measured value Fn was sequentially performed in the same manner, any one Fk−
Fk-1 becomes 1,500 or more,wherein a quartz resonator sensor (resonance frequency of 9 MHz, AT-cut, gold electrode) is used as the quartz resonator sensor, and the measurement is performed at a fundamental frequency of 27 MHz at room temperature (about 25°
C.) using the QCM.
- C. for 30 minutes, and then the quartz resonator sensor is quickly washed with pure water and dried, followed by the measurement of a resonance frequency using the QCM to obtain a measured value F1, and
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8. A low water content soft device for eye to be worn in the eye, having an elastic modulus of 100 kPa or more and 2,000 kPa or less, a water content of 10% by mass or less, a tensile elongation of 50% or more and 3,000% or less, and a dynamic contact angle (advancing angle) relative to a borate buffer of 80°
- or less, an iris-like pattern being formed on at least a part of the low water content soft device for eye.
- View Dependent Claims (10, 11)
- 9. A low water content soft device for eye, wherein a layer made of an acidic polymer and a basic polymer is formed on at least a part of the low water content soft device for eye, an iris-like pattern being formed on at least a part of the low water content soft device for eye.
- 12. A low water content soft contact lens to be worn in the eye, wherein a pattern promoting the exchange of lacrimal fluid between the low water content soft contact lens and the eye is formed.
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14. A method for producing a low water content soft contact lens, which comprises molding a base material using a mold made of a resin, and then perforating the base material before separating the base material from the mold made of a resin.
Specification