NUTRITIONAL COMPOSITIONS CONTAINING A NEUROLOGIC COMPONENT AND USES THEREOF

• US 20140199265A1
• Filed: 01/11/2013
• Published: 07/17/2014
• Est. Priority Date: 01/11/2013
• Status: Abandoned Application

• Current Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Original Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Inventors: Kuang, Chenzhong, Xiao, Yan, Poels, Eduard, Jouni, Zeina, Hondmann, Dirk
• Application Number:
  US13/739,787
• Publication Number:
  US 20140199265A1
• Time in Patent Office: Days
• US Class Current: 424/93.1
• CPC Class Codes: A23L 33/115 Fatty acids or derivatives thereof; Fats or oils
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/164 of a carboxylic acid with an aminoalcohol, e.g. ceramides
• CPC Class Codes: A61K 31/685 one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
• CPC Class Codes: A61K 31/688 both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
• CPC Class Codes: A61K 31/7032 attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
• CPC Class Codes: A61K 31/7068 having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
• CPC Class Codes: A61K 31/7072 having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine

Abstract

The present disclosure relates to nutritional compositions comprising a neurologic component, wherein, the neurologic component may promote brain and nervous system development and further provide neurological protection and repair. The neurologic component may include phosphatidylethanolamine, sphingomyelin, cytidine diphosphate-choline, ceramide, uridine, at least one ganglioside, and mixtures thereof. The disclosure further relates to methods of promoting brain and nervous system health by providing said nutritional compositions to target subjects, which includes pediatric subjects.

Claims

1. A nutritional composition comprising:

(i) a carbohydrate source;

(ii) a protein source;

(iii) a fat source;

(iv) lactoferrin; and

(v) a neurologic component comprising lutein and a nutrient selected from the group consisting of PE, sphingomyelin, CDP-choline, ceramide, uridine, at least one ganglioside and combinations of one or more thereof, wherein the neurologic component promotes neurogenesis when provided to a target subject.

2. The nutritional composition of claim 1, wherein PE is present in an amount from about 3.7 mg/100 kcal to about 37 mg/100 kcal.

3. The nutritional composition of claim 1, wherein sphingomyelin is present in an amount from about 0.15 mg/100 kcal to about 73 mg/100 kcal.

4. The nutritional composition of claim 1, wherein CDP-choline is present in an amount from about 7 mg/100 kcal to about 295 mg/100 kcal.

5. The nutritional composition of claim 1, wherein ceramide is present in an amount from about 2.2 mg/100 kcal to about 22 mg/100 kcal.

6. The nutritional composition of claim 1, wherein uridine is present in an amount from about 0.15 mg/100 kcal to about 37 mg/100 kcal.

7. The nutritional composition of claim 1, wherein ceramide is selected from the group consisting of N-octanoyl-D-threo-sphingosine, N—

(R,S) alpha-Hydroxydodecanoyl-D-erythro-sphingosine, and lactosylceramide.

8. The nutritional composition of claim 1, further comprising nutrients selected from the group consisting of a probiotic, a prebiotic, β

-glucan, an iron source, and combinations of one or more thereof.

9. The nutritional composition of claim 1, further comprising nutrients selected from the group consisting of DHA, ARA, resveratrol, cholesterol, lutein, and combinations of at least one or more thereof.

10. The nutritional composition of claim 1, wherein the nutritional composition is an infant formula.

11. A nutritional composition, comprising per 100 kcal:

(i) between about 6 g and about 22 g of a carbohydrate source;

(ii) between about 1 g and about 7 g of a protein source;

(iii) between about 1.3 g and about 7.2 g of a fat source;

(iv) lactoferrin; and

(v) a neurologic component comprising;

(a) between about 3.7 mg and about 37 mg of PE;

(b) between about 0.15 mg and about 73 mg of sphingomyelin;

(c) between about 37 mg and about 295 mg CDP-choline;

(d) between about 2.2 mg and about 22 mg ceramide;

(e) between about 0.7 mg and about 37 mg of uridine;

(f) between about 0.9 mg and about 14.8 mg of at least one ganglioside; and

(g) lutein;

wherein the neurologic component promotes neurogenesis when provided to a target subject.

12. The nutritional composition of claim 11, further comprising per 100 kcal between about 9.60×

10⁵ CFU and about 3.80×

10⁸ CFU of probiotic.

13. The nutritional composition of claim 11, further comprising per 100 kcal between about 0.3 g and about 1.2 g of prebiotic.

14. The nutritional composition of claim 11, wherein the nutritional composition further comprises per 100 kcal between about 4 mg and about 50 mg of DHA.

15. The nutritional composition of claim 11, further comprising at least one nutrient selected from the group consisting of ARA, DHA, lutein, resveratrol, and cholesterol.

16. A method for promoting brain and nervous system health, comprising:

providing to a target subject, a nutritional composition comprising a carbohydrate source, a protein source, a fat source, lactoferrin, and a neurologic component, wherein the neurologic component comprises lutein and at least one nutrient selected from the group consisting of PE, sphingomyelin, CDP-choline, uridine, ceramide, at least one ganglioside, and combinations of one or more thereof, wherein the neurologic component promotes neurogenesis when provided to the target subject.

17. The method of claim 16, wherein the target subject is a pediatric subject.

18. The method of claim 16, wherein the nutritional composition is an infant formula.

19. The method of claim 16, wherein nutritional composition further comprises at least one nutrient selected from the group consisting of consisting of DHA, ARA, lutein, resveratrol, and cholesterol.

20. The method of claim 16, wherein the nutritional composition further comprises at least one nutrient selected from the group consisting of a probiotic, a prebiotic, β

-glucan, and an iron source.