SYSTEM AND METHOD OF MODELING ERYTHROPOIESIS AND ITS MANAGEMENT
First Claim
1. A method of adjusting a patient'"'"'s undesired hematocrit and/or hemoglobin concentration to a value within a desired range at a predetermined time with an erythropoiesis stimulating agent (ESA) regimen comprising:
- a) obtaining patient parameters required for input into a model for predicting the patient'"'"'s hematocrit and/or hemoglobin concentration at a predetermined time with a selected ESA administration regimen;
b) employing the patient parameters and an initially selected EPO administration regimen in the model to predict the patient'"'"'s hematocrit and/or hemoglobin concentration at the predetermined time with the initially selected ESA administration regimen;
c) optionally, if the patient'"'"'s hematocrit and/or hemoglobin concentration is not predicted by the model to be in the desired range at the predetermined time, employing the model with one or more different ESA administration regimens until the model predicts that the patient'"'"'s hematocrit and/or hemoglobin concentration will be in the desired range at the predetermined time; and
d) administering ESA to the patient with the ESA administration regimen predicted to adjust the patient'"'"'s hematocrit and/or hemoglobin concentration to a value within the desired range at the predetermined time.
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Accused Products
Abstract
A method of adjusting a patient'"'"'s undesired hematocrit and/or hemoglobin concentration to a value within a desired range at a predetermined time with an erythropoiesis stimulating agent (ESA) regimen includes obtaining patient parameters required for input into a model for predicting the patient'"'"'s hematocrit and/or hemoglobin concentration at a predetermined time with a selected ESA administration regimen, and employing the patient parameters and an initially selected EPO administration regimen in the model to predict the patient'"'"'s hematocrit and/or hemoglobin concentration at the predetermined time with the initially selected ESA administration regimen. Optionally, if the patient'"'"'s hematocrit and/or hemoglobin concentration is not predicted by the model to be in the desired range at the predetermined time, the method includes employing the model with one or more different ESA administration regimens until the model predicts that the patient'"'"'s hematocrit and/or hemoglobin concentration will be in the desired range at the predetermined time. The method then includes administering ESA to the patient with an ESA administration regimen predicted to adjust the patient'"'"'s hematocrit and/or hemoglobin concentration to the desired range at the predetermined time. The method can be implemented in a computer system for adjusting a patient'"'"'s undesired hematocrit and/or hemoglobin concentration to a desired range at a predetermined time with an erythropoiesis stimulating agent (ESA) regimen.
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Citations
14 Claims
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1. A method of adjusting a patient'"'"'s undesired hematocrit and/or hemoglobin concentration to a value within a desired range at a predetermined time with an erythropoiesis stimulating agent (ESA) regimen comprising:
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a) obtaining patient parameters required for input into a model for predicting the patient'"'"'s hematocrit and/or hemoglobin concentration at a predetermined time with a selected ESA administration regimen; b) employing the patient parameters and an initially selected EPO administration regimen in the model to predict the patient'"'"'s hematocrit and/or hemoglobin concentration at the predetermined time with the initially selected ESA administration regimen; c) optionally, if the patient'"'"'s hematocrit and/or hemoglobin concentration is not predicted by the model to be in the desired range at the predetermined time, employing the model with one or more different ESA administration regimens until the model predicts that the patient'"'"'s hematocrit and/or hemoglobin concentration will be in the desired range at the predetermined time; and d) administering ESA to the patient with the ESA administration regimen predicted to adjust the patient'"'"'s hematocrit and/or hemoglobin concentration to a value within the desired range at the predetermined time. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A computer system for adjusting a patient'"'"'s undesired hematocrit and/or hemoglobin concentration to a value within a desired range at a predetermined time with an erythropoiesis stimulating agent (ESA) regimen, the computer system comprising:
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a) a user input means for determining patient parameters from a user; b) a digital processor coupled to receive determined patient data from the input means, wherein the digital processor executes a modeling system in working memory, wherein the modeling system; i) employs the patient parameters and an initially selected EPO administration regimen in the model to predict the patient'"'"'s hematocrit and/or hemoglobin concentration at the predetermined time with the initially selected ESA administration regimen; and ii) optionally, if the patient'"'"'s hematocrit and/or hemoglobin concentration is not predicted by the model to be in the desired range at the predetermined time, employs the model with one or more different ESA administration regimens until the model predicts that the patient'"'"'s hematocrit and/or hemoglobin concentration will be a value within in the desired range at the predetermined time; and c) an output means coupled to the digital processor, the output means provides to the user the patient'"'"'s hematocrit and/or hemoglobin concentration under the ESA administration regimen at the predetermined time. - View Dependent Claims (8, 9, 10, 11, 12)
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13. A method of determining an erythropoiesis stimulating agent (ESA) administration regimen to bring a patient'"'"'s hematocrit and/or hemoglobin concentration into a desired range at a predetermined time comprising:
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a) obtaining patient parameters required for input into a model for predicting the patient'"'"'s hematocrit and/or hemoglobin concentration at a predetermined time with a selected ESA administration regimen; b) employing the patient parameters and an initially selected EPO administration regimen in the model to predict the patient'"'"'s hematocrit and/or hemoglobin concentration at the predetermined time with the initially selected ESA administration regimen; and c) optionally, if the patient'"'"'s hematocrit and/or hemoglobin concentration is not predicted by the model to be in the desired range at the predetermined time, employing the model with one or more different ESA administration regimens until the model predicts that the patient'"'"'s hematocrit and/or hemoglobin concentration will be in the desired range at the predetermined time. - View Dependent Claims (14)
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Specification