NASAL DELIVERY

• US 20140202456A1
• Filed: 12/02/2013
• Published: 07/24/2014
• Est. Priority Date: 11/15/2000
• Status: Active Grant

• Current Assignee: OptiNose, Inc.
• Original Assignee: OptiNose AS (OptiNose, Inc.)
• Inventors: Djupesland, Per Gisle
• Granted Patent: US 9,468,727 B2
• Time in Patent Office: Days
• US Class Current: 128/200.21
• CPC Class Codes: A61B 5/085 Measuring impedance of respiratory organs or lung elasticity
• CPC Class Codes: A61B 5/097 Devices for facilitating collection of breath or for directing breath into or through measuring devices
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 11/001 Particle size control
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 11/006 operated by applying mechanical pressure to the liquid to be sprayed or atomised
• CPC Class Codes: A61M 11/007 Syringe-type or piston-type sprayers or atomisers
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 15/002 with air flow regulating means
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 15/0091 mechanically breath-triggered
• CPC Class Codes: A61M 15/0098 Activated by exhalation
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2202/04 Liquids
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/071 hand operated
• CPC Class Codes: A61M 2205/073 : Syringe, piston type
• CPC Class Codes: A61M 2205/13 : with means for the detection of operative contact with patient, e.g. lip sensor
• CPC Class Codes: A61M 2210/0668 : Middle ear
• CPC Class Codes: A61M 2230/43 : Composition of exhalation

Abstract

A nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device comprising: a delivery unit for delivering a flow entraining a substance to one nostril of a subject, the delivery unit including a nosepiece for fitting to a nostril of the subject; and a flow resistor unit for fitting to the other nostril of the subject, the flow resistor unit including a progressive resistor for progressively providing an increasing flow resistance to the delivered flow.

Claims

1. A nasal delivery device for delivering a flow entraining a substance to a nostril of a subject, including:

a nosepiece for fitting to a nostril of a subject; and

a flow resistor upstream of the outlet of the nosepiece to provide a predeterminable flow resistance to the delivered flow.

2. The delivery device of claim 1, wherein the flow resistor is a progressive resistor for progressively providing an increasing flow resistance to the delivered flow.

3. The delivery device of claim 1, wherein the flow resistor is a fixed resistor for providing a predeterminable resistance to the delivered flow.

4. The delivery device of claim 1, further including:

a substance supply unit which is actuatable to supply a substance.

5. The delivery device of claim 4, wherein the substance supply unit is configured to be actuatable to supply a substance at a predeterminable pressure.

6. The delivery device of claim 4, wherein the substance supply unit is configured to be actuatable to supply a substance at a predeterminable flow rate.

7. The delivery device of claim 4, wherein the substance supply unit is configured to be actuatable to supply a substance at one or both of a predeterminable pressure and a predeterminable flow rate.

8. The delivery device of claim 1, further including:

a mouthpiece through which the subject in use exhales.

9. The delivery device of claim 8, further including:

a flow channel fluidly connecting the nosepiece and the mouthpiece, whereby exhaled air from an exhalation breath is delivered through the nosepiece.

10. The delivery device of claim 1, further including:

a flow channel fluidly connected to the nosepiece through which a gas flow, separate to an exhaled air flow from an exhalation breath of a subject, is in use delivered; and

a gas supply unit for supplying a gas flow to the flow channel.

11. The delivery device of claim 1, wherein the substance supply unit includes a dosing unit for supplying a substance.

12. The delivery device of claim 11, wherein the dosing unit comprises a nebulizer for supplying an aerosol.

13. The delivery device of claim 11, wherein the dosing unit comprises an aerosol canister for supplying an aerosol.

14. The delivery device of claim 11, wherein the dosing unit comprises a delivery pump unit for supplying an aerosol.

15. The delivery device of claim 14, wherein the dosing unit comprises a liquid pump unit for supplying a liquid aerosol.

16. The delivery device of claim 14, wherein the dosing unit comprises a powder pump unit for supplying a powder aerosol.

17. The delivery device of claim 11, wherein the dosing unit comprises a powder delivery unit for delivering a powder aerosol.