DIAGNOSTIC METHOD FOR HIGH SENSITIVITY DETECTION OF COMPONENT CONCENTRATIONS IN HUMAN GAS EMISSIONS

• US 20140211208A1
• Filed: 01/28/2013
• Published: 07/31/2014
• Est. Priority Date: 03/19/2001
• Status: Active Grant

• Current Assignee: C. Kumar N. Patel, Narasimhan L. Ravi
• Original Assignee: C. Kumar N. Patel, Narasimhan L. Ravi
• Inventors: Patel, C. Kumar N., Narasimhan, L. Ravi
• Granted Patent: US 8,994,947 B2
• Time in Patent Office: Days
• US Class Current: 356/437
• CPC Class Codes: G01N 2021/1704 in gases
• CPC Class Codes: G01N 21/1702 with opto-acoustic detection, e.g. for gases or analysing solids
• CPC Class Codes: G01N 21/39 using tunable lasers
• CPC Class Codes: G01N 21/59 Transmissivity G01N21/25 takes precedence
• CPC Class Codes: G01N 2201/022 Casings
• CPC Class Codes: G01N 2201/06113 Coherent sources; lasers

Abstract

A method for detecting component concentrations in human gas emissions such as breath and gas emitted from skin. A gas sample containing a specified component is collected into a gas cell using a pump and a series of valves to draw the gas sample into the cell and control the gas pressure within the cell. A tunable optical radiation beam is passed through the gas cell and the amount of energy absorbed by the specified component may be measured indirectly by taking the difference between the incident and emerging beam energy or directly by optoacoustic methods. Concentrations of the specified component as small as 0.1 ppB may be determined. Additionally, the tunable optical radiation beam may be multiplexed for use with a plurality of systems utilizing the beam for medical purposes.

Claims

1. A diagnostic method for high sensitivity detection of component concentrations in human gas emissions comprising:

(a) collecting a gas sample in a gas cell, wherein the gas sample may contain a specified component being associated with a plurality of fundamental absorption peak frequencies;

(b) passing a tunable optical radiation beam through the gas cell (1) when the gas cell contains a reference sample having a known concentration of the specified component and (2) when the gas cell contains the gas sample, wherein the frequency of the tunable optical radiation beam comprises a modulation frequency superimposed on a base frequency, and the base frequency is swept repeatedly through a series of frequencies such that the series of frequencies comprises at least one of the fundamental absorption peak frequencies;

(c) measuring, after the tunable optical beam passes through the gas cell, as first signal outputs an amplitude of the tunable optical radiation beam at the modulation frequency, and as second signal outputs a power of the tunable optical radiation beam; and

(d) determining a concentration of the specified component in the gas sample using the first signal outputs and the second signal outputs obtained from the reference sample and the gas sample.

2. The method of claim 1, wherein the gas cell is placed in an optical cavity.

3. The method of claim 1, wherein the gas sample is collected from expired human breath.

4. The method of claim 1, wherein the gas sample is collected from gas emissions from human skin.

5. The method of claim 4, wherein the step of collecting the gas sample further comprises:

(a) sealing a collection chamber having a first side with a planar opening by placing the first side firmly against skin;

(b) delivering into the collection chamber a steady flow of an inert gas; and

(c) collecting the gas sample from the collection chamber into the gas cell.

6. The method of claim 1, wherein the specified component is ammonia.

7. The method of claim 1, wherein the specified component is nitric oxide.

8. The method of claim 1, wherein the specified component comprises a ketone.

9. The method of claim 1, wherein the specified component comprises an alcohol.

10. The method of claim 1, wherein the specified component comprises an alkane.

11. The method of claim 1, wherein said tunable optical radiation beam is multiplexed so that the beam may be passed through one or more of a plurality of gas cells.

12. The method of claim 11 further comprising detecting when a patient connects to one of the plurality of gas cells, said patient providing the gas sample.

13. The method of claim 11 further comprising notifying a patient when to connect to one of the plurality of gas cells, said patient providing the gas sample.

14. The method of claim 11 further comprising notifying the patient of a completed diagnosis after determining the concentration of the specified component.

15. The method of claim 11 further comprising the tunable optical radiation beam being simultaneously passes through at least two of the plurality of gas cells.

16. A diagnostic method for high sensitivity detection of component concentrations in human gas emissions comprising:

(a) collecting a gas sample in a gas cell, wherein the gas sample may contain a specified component being associated with a plurality of fundamental absorption peak frequencies;

(b) passing a tunable optical radiation beam through the gas cell (1) when the gas cell contains a reference sample having a known concentration of the specified component and (2) when the gas cell contains the gas sample, wherein the frequency of the tunable optical radiation beam comprises a modulation frequency superimposed on a base frequency, and the base frequency is swept repeatedly through a series of frequencies such that the series of frequencies comprises at least one of the fundamental absorption peak frequencies;

(c) measuring, after the tunable optical beam passes through the gas cell, as first signal outputs an amplitude of the tunable optical radiation beam at the modulation frequency when the gas cell contains the reference sample, as second signal outputs a power of the tunable optical radiation beam when the gas cell contains the reference sample, as third signal outputs an amplitude of the tunable optical radiation beam at the modulation frequency when the gas cell contains the gas sample, and as fourth signal outputs a power of the tunable optical radiation beam when the gas cell contains the gas sample; and

(d) determining a concentration of the specified component in the gas sample using the following equation;