PROCESSING PARTICLE-CONTAINING SAMPLES
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Accused Products
Abstract
A microfluidic device includes an input port for inputting a particle-containing liquidic samples into the device, a retention member, and a pressure actuator. The retention member is in communication with the input port and is configured to spatially separate particles of the particle-containing liquidic sample from a first portion of the liquid of the particle containing fluidic sample. The pressure actuator recombines at least some of the separated particles with a subset of the first portion of the liquid separated from the particles. The device can also include a lysing chamber that receives the particles and liquid from the retention member. The lysing chamber thermally lyses the particles to release contents thereof.
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Citations
26 Claims
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1-6. -6. (canceled)
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7. A microfluidic valve contained in a microfluidic cartridge to selectively obstruct passage of material in a microfluidic network of the microfluidic cartridge, the valve comprising:
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a side channel in communication with a main channel of the microfluidic network, the side channel and the main channel being located in a common plane of the microfluidic cartridge; a chamber in communication with the side channel and being located vertically above the side channel; and a thermally responsive substance disposed within the side channel. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A microfluidic valve contained in a microfluidic cartridge to selectively obstruct passage of material in a microfluidic network of the microfluidic cartridge, the valve comprising:
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a first layer; a second layer, the first and second layer defining a side channel therebetween, the side channel being in communication with a main channel of the microfluidic network; a third layer, the second and third layer defining a chamber therebetween, the chamber being in communication with the side channel; and a thermally responsive substance disposed within the side channel. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26)
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Specification