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IMPLANTABLE-GLUCOSE RESPONSIVE INSULIN DELIVERY DEVICE

  • US 20140213963A1
  • Filed: 03/31/2014
  • Published: 07/31/2014
  • Est. Priority Date: 05/05/2010
  • Status: Active Grant
First Claim
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1. A biocompatible insulin delivery device comprising a reservoir for insulin, a glucose-responsive plug that seals the reservoir, and optionally comprising a protective microporous membrane covering the exposed surface of the glucose-responsive plug and further sealing the reservoir, wherein the plug comprises a polymeric matrix having an inorganic component and a stimulus-responsive component adapted to alter the porosity of the plug in response to a stimulus and wherein the plug functions to release insulin from the reservoir in response to a hyperglycemic glucose concentration and to prevent insulin release from the reservoir in response to a hypoglycemic glucose concentration.

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