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TRANSFORMATION OF DRUG CYCLODEXTRIN COMPLEX COMPOSITIONS INTO COMPOSITIONS OF MIXTURES OF LIPID VESICLE ENCAPSULATED DRUG AND CYCLODEXTRIN DRUG COMPLEXES

  • US 20140220112A1
  • Filed: 02/03/2014
  • Published: 08/07/2014
  • Est. Priority Date: 02/01/2013
  • Status: Abandoned Application
First Claim
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1. A pharmaceutical formulation of a sparingly water-soluble therapeutic agent, said formulation comprising:

  • (a) a pharmaceutically acceptable diluent;

    (b) a complex between said sparingly water-soluble therapeutic agent and a solubility enhancing agent dissolved in said diluent; and

    (c) a population of liposomal lipid vesicles suspended in said diluent, wherein said lipid vesicles comprise a lipid membrane encapsulating an internal aqueous medium comprising a first fraction of said sparingly water-soluble therapeutic agent, which is not complexed with a solubility enhancing agent.

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