Device and Methods for Enhanced Multi-Delivery of Biologically Active Substances Into an Organism and To Prevent Local Irritation

• US 20140221905A1
• Filed: 04/04/2014
• Published: 08/07/2014
• Est. Priority Date: 05/19/2009
• Status: Active Grant

• Current Assignee: Lerner, Eduard N.
• Original Assignee: Lerner, Eduard N.
• Inventors: Lerner, Eduard N.
• Granted Patent: US 9,492,661 B2
• Time in Patent Office: Days
• US Class Current: 604/21
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0043 Nose
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

Transnasal delivery of medication directly to a patient'"'"'s brain is achieved using an iontophoresis wire cooperable with a medication administration device. A controller regulates an electric charge to the iontophoresis wire. The iontophoresis wire is insertable into each nasal cavity. This wire is preferably encased in a tube, through which the medication will be transnasally delivered. A cleaning solution may also be delivered to the nasal cavity after treatment to reduce irritation from the iontophoresis.

Claims

1. A device for transnasally delivering medication directly to a patient'"'"'s brain, the device comprising:

an iontophoresis wire cooperable with a medication administration device, the iontophoresis wire being insertable into each nasal cavity through which the medication will be transnasally delivered; and

a controller regulating an electric charge to the iontophoresis wire.

2. A device for transnasally delivering medication according to claim 1, further comprising a delivery device for a cleaning solution.

3. A device for transnasally delivering medication according to claim 2, wherein the delivery device for the cleaning solution comprises a nose spray.

4. A device for transnasally delivering medication according to claim 1, wherein the medication administration device comprises a container holding the medication in liquid form attached to the iontophoresis wire.

5. A device for transnasally delivering medication according to claim 4, wherein the container comprises an absorbent material.

6. A device for transnasally delivering medication directly to a patient'"'"'s brain, the device comprising:

a medication administration tube and a cleaning solution tube for each nasal cavity through which the medication will be transnasally delivered;

an iontophoresis wire cooperable with the medication administration tube;

a controller with access to a source of the medication and a cleaning solution, wherein the controller is in fluid communication with the medication administration tube and the cleaning solution tube, and wherein the controller regulates an electric charge to the iontophoresis wire, the controller supplying the medication to the medication administration tube and the cleaning solution to the cleaning solution tube; and

a passive electrode.

10. A device for transnasally delivering medication according to claim 10, wherein the passive electrode is rubber coated, and wherein the device further comprises a soft substance positionable between the passive electrode and the patient'"'"'s head, the soft substance being soaked in sodium chloride.

7. A device for transnasally delivering medication according to claim 10, wherein the iontophoresis wire is disposed within the medication administration tube.

8. A device for transnasally delivering medication according to claim 10, wherein the controller is programmed to regulate a pressure and a dose of the medication.

9. A device for transnasally delivering medication according to claim 10, wherein the electric charge on the iontophoresis wire is dependent on a charge of the medication being delivered.