CLOT DETECTION BASED ON SIGNAL-TIME HISTORY DIAGNOSTICS

• US 20140221911A1
• Filed: 01/27/2014
• Published: 08/07/2014
• Est. Priority Date: 02/01/2013
• Status: Abandoned Application

• Current Assignee: Edwards Lifesciences Corporation
• Original Assignee: Edwards Lifesciences Corporation
• Inventors: Higgins, Michael, Van Wieren, Paul S.
• Application Number:
  US14/165,297
• Publication Number:
  US 20140221911A1
• Time in Patent Office: Days
• US Class Current: 604/65
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61M 1/3653 Interfaces between patient blood circulation and extra-corporal blood circuit
• CPC Class Codes: A61M 1/3659 Cannulae pertaining to extracorporeal circulation
• CPC Class Codes: A61M 2205/505 Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 5/16854 by monitoring line pressure
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

The present disclosure provides a sensor system that includes a blood access device, a flow controller, and an analyte sensor. The system is configured to flush or draw a volume of fluid through the blood access device at least once; determine a signal-time history corresponding to signals received from the sensor; determine a duration of a portion of the signal-time history; determine whether the duration is greater than a predetermined threshold value; and detect the occlusion in the blood access device when the duration is greater than the predetermined threshold value.

Claims

1. A system for detecting an occlusion in a blood access device, the system comprising:

a blood access device in fluid communication with a calibrant solution source and a circulatory system of a patient;

a flow controller configured to sequentially draw blood from the circulatory system and flush fluid from the calibrant solution source through the blood access device, the sequential draw and flush defining a draw and flush cycle;

a sensor coupled to the blood access device and configured to generate one or more portions of a signal-time history associated with the draw and flush cycle;

a memory;

a processor; and

a computing module, stored in the memory, executable by the processor, and configured to cause the processor to;

operate the flow controller to sequentially draw blood and flush fluid through the blood access device;

determine the signal-time history for the draw and flush cycle from the sensor;

determine a time duration of a predetermined portion of the signal-time history associated with the draw and flush cycle;

determine whether the time duration is greater than a predetermined threshold value; and

detect an occlusion in the blood access device when the time duration of the signal-time history is greater than the predetermined threshold value.

2. The system of claim 1, wherein the sensor is a glucose sensor.

3. The system of claim 1, further comprising halting display of information on a display when the occlusion is detected.

4. The system of claim 1, wherein the predetermined threshold value is determined based on a standard signal-time history analyzed when an occlusion is not present.

5. A method for detecting an occlusion in a blood access device, the method comprising:

providing a blood access device in fluid communication with a calibrant solution source and a circulatory system of a patient;

providing a flow controller configured to sequentially draw blood from the circulatory system and flush fluid from the calibrant solution source through the blood access device, the sequential draw and flush defining a draw and flush cycle;

providing a sensor coupled to the blood access device and configured to generate one or more portions of a signal-time history associated with the draw and flush cycle; and

providing a processor for executing computer program code stored in a non-transitory computer-readable medium to cause the processor to;

operate the flow controller to sequentially draw blood and flush fluid through the blood access device;

determine the signal-time history for the draw and flush cycle from the sensor;

determine a time duration of a predetermined portion of the signal-time history associated with the draw and flush cycle;

determine whether the time duration is greater than a predetermined threshold value; and

detect an occlusion in the blood access device when the time duration of the signal-time history is greater than the predetermined threshold value.

6. The method of claim 5, wherein the sensor is a glucose sensor.

7. The method of claim 5, further comprising halting display of information on a display when the occlusion is detected.

8. The method of claim 5, wherein the predetermined threshold value is determined based on a standard signal-time history analyzed when an occlusion is not present.

9. A computer program product for detecting an occlusion in a blood access device, the computer program product comprising:

a non-transitory computer-readable medium comprising a set of codes for causing a computer to;

operate a flow controller to sequentially draw blood and flush fluid through a blood access device, wherein the blood access device is in fluid communication with a calibrant solution source and a circulatory system of a patient;

determine a signal-time history for the draw and flush cycle from a sensor, wherein the sensor is coupled to the blood access device;

determine a time duration of a predetermined portion of the signal-time history associated with the draw and flush cycle;

determine whether the time duration is greater than a predetermined threshold value; and

detect an occlusion in the blood access device when the time duration of the signal-time history is greater than the predetermined threshold value.

10. The computer program product of claim 9, wherein the sensor is a glucose sensor.

11. The computer program product of claim 9, further comprising halting display of information on a display when the occlusion is detected.

12. The computer program product of claim 9, wherein the predetermined threshold value is determined based on a standard signal-time history analyzed when an occlusion is not present.