DIAGNOSTIC METHODS AND APPARATUS

• US 20140221941A1
• Filed: 06/28/2012
• Published: 08/07/2014
• Est. Priority Date: 06/28/2011
• Status: Active Grant

• Current Assignee: Forsight Vision4, Inc. (Roche Holding AG)
• Original Assignee: Forsight Vision4, Inc. (Roche Holding AG)
• Inventors: Erickson, Signe, Doud, Darren, de Juan, Eugene Jr., Alster, Yair, Reich, Cary J., Farinas, Kathleen Cogan
• Granted Patent: US 10,398,592 B2
• Time in Patent Office: Days
• US Class Current: 604/294
• CPC Class Codes: A61B 10/0045 Devices for taking samples of body liquids devices for taking blood samples A61B5/15
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61P 27/02 Ophthalmic agents

Abstract

An apparatus to treat a patient comprises a container to receive fluid of a device implanted in the eye. The fluid of the device can be analyzed to determine a component of the vitreous humor of the eye.

Claims

1. An apparatus to treat a patient having an eye, the apparatus comprising:

a processor system having a tangible medium comprising instructions of a computer program embodied thereon, the instructions configured to receive data of a fluid of a device implanted in an eye.

2. The apparatus of claim 1, wherein fluid comprises a component of a fluid of the eye.

3. The apparatus of claim 1, wherein fluid comprises one or more a components of a formulation to treat the eye.

4. The apparatus of claim 1, wherein one or more components comprise a therapeutic agent and a stabilizer.

5. The apparatus of claim 1, wherein processor system comprises instructions to identify the eye to modify treatment of the eye and transmit a signal to a physician.

6. The apparatus of claim 1, wherein the processor system comprises instructions to identify the eye and transmit a signal to a physician to one or more of modify, change, adjust, or change a treatment of the eye based on the data of the fluid of the device implanted in the eye.

7. The apparatus of claim 1, wherein the processor system comprises instructions to identify a therapeutic agent of the eye, a pathogen of the eye or an endogen of the eye based on the fluid of the implant.

8. The apparatus of claim 1, wherein the device comprises a porous structure to deliver a therapeutic agent and wherein the fluid of the device comprises a component of a fluid of the eye diffused through the porous structure into a chamber of the device.

9. The apparatus of claim 8, wherein the fluid of the device comprises a fluid exchanged from the chamber of the implanted device to a container.

10. The apparatus of claim 8, wherein the fluid of the eye comprises a one or more of an aqueous humor of the eye or a vitreous humor of the eye.

11. The apparatus of claim 8, wherein the fluid of the eye comprises a vitreous humor and wherein the fluid of the device comprises a component of vitreous humor passed through the porous structure and wherein the data of the fluid of the eye comprises data of the component of the vitreous humor of the eye.

12. The apparatus of claim 11, wherein the processor system comprises instructions to adjust a treatment of a therapeutic agent passed through the porous structure.

13. The apparatus of claim 11, wherein the processor system comprises instructions to adjust a treatment of a therapeutic agent not passed through the porous structure.

14. The apparatus of claim 5, wherein the processor system comprises instructions to receive a first identifier corresponding to first data of a first fluid of the implanted device and a second identifier corresponding to second data of a second fluid of the implanted device and wherein the instructions are configured to compare the first data of the first fluid of the implanted device to the second data of the second fluid of the implanted device.

15. The apparatus of claim 1, wherein the processor system comprises instructions to determine a function of the device implanted in the eye.

16. The apparatus of claim 15, wherein the processor system comprises instructions to determine the function of the device based on one or more components of a formulation placed in the device and wherein the one or more components of the formulation comprise one or more of a therapeutic agent, a marker to measure device function, a salt, a surfactant, a stabilizer or a particle.

17. The apparatus of claim 15, wherein the processor system comprises instructions to determine the function of the device based on measurements of two or more components of a formulation placed in the device, the two or more components comprising a therapeutic agent and one or more of a marker to measure device function, a salt, a surfactant, a stabilizer or a particle.

18. The apparatus of claim 15, wherein the function of the device comprises one or more of a refill efficiency, a rate of release of a therapeutic agent, or a stability of a therapeutic agent.

19. The apparatus of claim 18, wherein the processor system comprises instructions to determine the refill efficiency of the therapeutic agent and wherein the refill efficiency corresponds to a percentage of the therapeutic agent.

20. The apparatus of claim 18, wherein the processor system comprises instructions to determine stability of the therapeutic agent wherein the stability of the therapeutic agent corresponds to an amount of aggregated therapeutic agent of the fluid.

21-121. -121. (canceled)