IMPLANTABLE DEVICE WITH INTRAVESICAL TOLERABILITY AND METHODS OF TREATMENT
First Claim
1. A drug delivery device for deployment within the bladder of a human patient which is well tolerated by the patient, comprising:
- an elongated elastic body comprising a first end, an opposed second end, and an annular portion disposed between the first and second ends, wherein the elastic body comprises a drug reservoir lumen defined at least in part by the annular portion; and
a drug formulation loaded in the drug reservoir lumen, the drug formulation comprising a drug,wherein the device has a retention shape having (i) dimensions that provide intravesical mobility and that prevent voiding of the medical device through the urethra, and (ii) dimensions, buoyancy, or both, that exclude the medical device from entering the orifices of the ureters.
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Accused Products
Abstract
Intravesical devices are provided that are wholly deployable within the bladder of a patient in need of treatment and are well tolerated by the patient. The device may include an elastic body having a retention shape having (i) dimensions that provide intravesical mobility and that prevent voiding of the medical device through the urethra, and (ii) dimensions, buoyancy, or both, that exclude the medical device from entering the orifices of the ureters. The elastic body may exert a maximum acting force less than 1N when compressed to a shape with a maximum dimension in any dimension of 3 cm. The device may include a drug for controlled release within the bladder, for treatment of the bladder or a regional tissue. Methods of treatment are also provided that include selecting a patient in need of treatment in the bladder where tolerability of the treatment is a primary concern.
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Citations
23 Claims
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1. A drug delivery device for deployment within the bladder of a human patient which is well tolerated by the patient, comprising:
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an elongated elastic body comprising a first end, an opposed second end, and an annular portion disposed between the first and second ends, wherein the elastic body comprises a drug reservoir lumen defined at least in part by the annular portion; and a drug formulation loaded in the drug reservoir lumen, the drug formulation comprising a drug, wherein the device has a retention shape having (i) dimensions that provide intravesical mobility and that prevent voiding of the medical device through the urethra, and (ii) dimensions, buoyancy, or both, that exclude the medical device from entering the orifices of the ureters. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification