Transdermal Integrated Actuator Device, Methods of Making and Using Same

• US 20140228736A1
• Filed: 03/05/2014
• Published: 08/14/2014
• Est. Priority Date: 03/11/2002
• Status: Active Grant

• Current Assignee: ​Passport Technologies, Inc.
• Original Assignee: Nitto Denko Corporation
• Inventors: Eppstein, Jonathan, McRae, Stuart
• Granted Patent: US 9,486,616 B2
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/0061 Methods for using microneedles
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2210/04 Skin
• CPC Class Codes: A61M 2230/20 Blood composition characteristics
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61N 1/0424 Shape of the electrode
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0476 Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428
• CPC Class Codes: A61N 1/326 for promoting growth of cells, e.g. bone cells
• CPC Class Codes: A61N 1/327 for enhancing the absorption properties of tissue, e.g. by electroporation

Abstract

Providing a method for monitoring an analyte extracted from a patient and delivering a permeant composition to the patient. The method includes the steps of a) contacting a poration device to a tissue membrane of the patient, the poration device including at least one porator array; b) actuating poration of the tissue membrane using the at least one porator array in the poration device; c) extracting the analyte from the porated tissue membrane by way of the at least one porator array; d) analyzing the analyte to determine a concentration of the analyte within the tissue membrane; and e) delivering a permeant composition to the tissue membrane by way of the at least one porator array.

Claims

1. An method of monitoring an analyte extracted from a patient and delivering a permeant composition to the patient, the method comprising the steps of:

a) contacting a poration device to a tissue membrane of the patient, the poration device comprising at least one porator array;

b) actuating poration of the tissue membrane using the at least one porator array in the poration device;

c) extracting the analyte from the porated tissue membrane by way of the at least one porator array;

d) analyzing the analyte to determine a concentration of the analyte within the tissue membrane; and

e) delivering a permeant composition to the tissue membrane by way of the at least one porator array.

2. The method according to claim 1, wherein the poration device comprises:

i) an outer body defining a top of the poration device, the outer body containing a cavity;

ii) a controller board comprising driving electronics and a battery, the controller board being positioned within the cavity;

iii) a first reservoir comprising a top, side walls and a bottom, the top comprising a thin film top plate abutting a bottom of the controller board and fitting within said cavity; and

iv) a tissue interface layer for contacting the tissue membrane, the tissue interface layer containing the at least one porator array and a second reservoir, wherein the tissue interface layer forms the bottom of the first reservoir of the poration device.