MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH
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Abstract
The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.
13 Citations
278 Claims
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1-241. -241. (canceled)
- 242. An ingestible composition comprising a compound having structural Formula (IIIb), or a tautomer, salt, solvate, and/or ester thereof;
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258. A liquid or solid concentrate formulation comprising a compound of Formula (IIIb), or a tautomer, salt, solvate, and/or ester thereof;
- and an ingestible carrier;
- and an ingestible carrier;
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259. A dry powdered beverage mix comprising a compound of Formula (IIIb), or a tautomer, salt, solvate, and/or ester thereof;
- 260. A method of preparing a final beverage product comprising contacting a first beverage product with a solid or liquid concentrate composition comprising a compound having structural Formula (IIIb), or a tautomer, salt, solvate, and/or ester thereof;
Specification