METHODS AND COMPOSITIONS FOR MODULATING AN IMMUNE RESPONSE
First Claim
1. A multispecific binding protein comprising a first binding site that specifically binds to a target cell antigen, a second binding site that specifically binds to a cell surface receptor on an immune cell, and a third binding site that specifically binds to cell surface modulator on the immune cell.
1 Assignment
0 Petitions
Accused Products
Abstract
Provided are multispecific binding proteins and methods for using these multispecific binding proteins to modulate the activation state of immune cells, such as T-cells (e.g., cytotoxic T-cells). Also provided are methods of modulating an immune response (e.g., cell killing by cytotoxic T-cells) in a subject (e.g., a human subject). Also provided are nucleic acids, expression vectors and host cells encoding the multispecific binding proteins.
81 Citations
82 Claims
- 1. A multispecific binding protein comprising a first binding site that specifically binds to a target cell antigen, a second binding site that specifically binds to a cell surface receptor on an immune cell, and a third binding site that specifically binds to cell surface modulator on the immune cell.
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3-5. -5. (canceled)
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10. (canceled)
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12. (canceled)
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15-17. -17. (canceled)
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19. (canceled)
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26-27. -27. (canceled)
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29. (canceled)
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30. A therapeutic combination comprising:
- a first multispecific binding protein comprising a first binding site that specifically binds to a target cell antigen, and a second binding site that specifically binds to an immune cell receptor complex component on the immune cell; and
a second multispecific binding protein comprising a first binding site that specifically binds to a target cell antigen, and a second binding site that specifically binds to a cell surface modulator on the immune cell. - View Dependent Claims (31, 32, 41, 42, 43, 44, 45)
- a first multispecific binding protein comprising a first binding site that specifically binds to a target cell antigen, and a second binding site that specifically binds to an immune cell receptor complex component on the immune cell; and
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33-40. -40. (canceled)
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49-50. -50. (canceled)
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51. A multispecific binding protein comprising:
- a first binding site that specifically binds to a first T-cell modulator; and
a second binding site that specifically binds to a second T-cell modulator. - View Dependent Claims (64, 65, 66, 67, 70, 72)
- a first binding site that specifically binds to a first T-cell modulator; and
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52-63. -63. (canceled)
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68-69. -69. (canceled)
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71. (canceled)
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73. (canceled)
Specification