SYSTEM AND METHOD FOR INTEGRATION OF MOBILE DEVICE IMAGING WITH MICROCHIP ELISA
First Claim
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1. A system for point-of-care (POC) testing of biological samples for biomarkers indicative of a predetermined pathological condition, the system comprising:
- a microchip system configured to receive a biological sample secured from a patient and provide colorimetric biomarker feedback indicative of a testing related to the predetermined pathological condition;
a mobile device configured to access a communications network and having a processor configured to;
access a camera configured to acquire color images of the colorimetric biomarker feedback;
determine a color intensity of at least a selected portion of the color image;
correlate the color intensity of the selected portion of the color image with a biomarker concentration; and
generate a report regarding the concentration of the biomarker concentration.
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Abstract
A system and method for analyzing a biomarker in a biological sample is provided. A biological sample is loaded onto a microchip and an enzyme-linked immunosorbent assay specific to the biomarker is performed on the microchip. A color image of the microchip is generated using a mobile device and a color intensity of a selected portion of the color image is determined. The color intensity is correlated with a biomarker concentration using a baseline curve calculation and the concentration of the biomarker is then reported.
53 Citations
26 Claims
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1. A system for point-of-care (POC) testing of biological samples for biomarkers indicative of a predetermined pathological condition, the system comprising:
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a microchip system configured to receive a biological sample secured from a patient and provide colorimetric biomarker feedback indicative of a testing related to the predetermined pathological condition; a mobile device configured to access a communications network and having a processor configured to; access a camera configured to acquire color images of the colorimetric biomarker feedback; determine a color intensity of at least a selected portion of the color image; correlate the color intensity of the selected portion of the color image with a biomarker concentration; and generate a report regarding the concentration of the biomarker concentration. - View Dependent Claims (2, 3, 5, 6, 8, 10, 11, 12)
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4. (canceled)
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7. (canceled)
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9. (canceled)
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13. A method for analyzing a biomarker in a biological sample, the steps of the method comprising:
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a) loading the biological sample onto a microchip; b) performing an enzyme-linked immunosorbent assay specific to the biomarker on the microchip; c) generating a color image of the microchip using one of a mobile device and a lensless charge coupled device; d) determining a color intensity of a selected portion of the color image; e) correlating the color intensity with a biomarker concentration using a baseline curve calculation; and f) reporting the concentration of the biomarker. - View Dependent Claims (14, 15, 17, 18, 19, 20, 22, 23)
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16. (canceled)
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21. (canceled)
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24. (canceled)
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25. A portable test system for mobile device camera-based analysis of biomarker concentrations in biological samples applied to a microchip, the system comprising:
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an enclosure adapted to receive the microchip, the enclosure including an imaging aperture large enough to allow imaging of the microchip through the imaging aperture using the mobile device camera; at least one light source adapted to illuminate the microchip; and a power source adapted to power the at least one light source. - View Dependent Claims (26)
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Specification