Composition with Sustained Antimicrobial Activity

• US 20140243417A1
• Filed: 05/01/2014
• Published: 08/28/2014
• Est. Priority Date: 11/03/2011
• Status: Abandoned Application

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta M., Dongre, Santoshkumar
• Application Number:
  US14/267,403
• Publication Number:
  US 20140243417A1
• Time in Patent Office: Days
• US Class Current: 514/635
• CPC Class Codes: A01N 47/40 the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/14 Quaternary ammonium compounds, e.g. edrophonium, choline betaines A61K31/205
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/39 Derivatives containing from 2 to 10 oxyalkylene groups
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations

Abstract

Disclosed herein are compositions comprising benzyl alcohol, one or more cationic antimicrobial agent, and one or more emollient, the combination of which results in persistent antimicrobial activity after application to the skin. The compositions optionally further comprise an organic acid and/or a zinc salt, such as zinc gluconate, as an anti-irritant.

Claims

1. A composition for topical application comprising:

(i) benzyl alcohol at a concentration of between about 0.1 and about 5% w/w;

(ii) one or more cationic antimicrobial agent selected from the group consisting of a quaternary ammonium compound, a biguanide, and a combination thereof, wherein the quaternary ammonium compound, if present, is at a concentration of between about 0.05 and about 1% w/w and the biguanide, if present, is at a concentration of between about 0.05 to about 3.0% w/w; and

(iii) one or more emollient selected from the group consisting of dipropylene glycol, farnesol, and combinations thereof, at a concentration effective in producing persistent antimicrobial activity after application to the skin.

2. The composition of claim 1, further comprising an organic acid.

3. The composition of claim 2, where the organic acid is selected from the group consisting of lactic acid, citric acid, glycolic acid, salicylic acid, mandelic acid and benzoic acid.

4. The composition of claim 1, further comprising a zinc salt as an anti-irritant.

5. The composition of claim 1, further comprising an anti-irritant selected from the group consisting of bisabolol, aloe vera gel, aloe leaf extract, and combinations thereof.

6. The composition of claim 1, further comprising a component selected from the group consisting of propylene glycol, glycerin, polyglycerol, butylene glycol, pentylene glycol, hexanediol, octanediol, ethyl hexyl glycerin, caprylic triglyceride, capric triglyceride, panthenol, lauric alcohol, emu oil, grapeseed oil, olive oil, and combinations thereof.

7. The composition of claim 1, further comprising a polyethylene oxide polymer.

8. The composition of claim 1, further comprising oat flour, oat extract or combinations thereof.

9. The composition of claim 1, which is a formulation selected from the group consisting of soap, hand sanitizer, cream, lotion, splash, astringent and wipe.

10. A method of providing a skin surface with a persistent antimicrobial activity, comprising treating the skin surface with a composition according to claim 1.

11. A composition for topical application comprising:

(i) benzyl alcohol at a concentration of between about 0.1 and about 5% w/w;

(ii) polyaminopropyl biguanide at a concentration of between about 0.05 and about 3.0% w/w; and

(iv) oat beta glucan, oat flour, oat extract or a combination thereof.