ASSAYS FOR ULTRASOUND MEDIATED DELIVERY
First Claim
1. A device comprising:
- an ultrasound therapy module (112) configured for, automatically and without need for user intervention, performing ultrasound mediated delivery so as to deliver a therapeutic agent via pressure-mediated, rather than temperature-mediated, effects, said device being configured for, automatically and without need for user intervention, proceeding based on quantitative feedback derived from the delivering.
1 Assignment
0 Petitions
Accused Products
Abstract
Ultrasound mediated delivery (USMD), real-time quantitative feedback derived (S264) therefrom, and proceeding by the system based on the feedback all are, in some embodiments, operable automatically and without need for user intervention. USMD may occur in a clinical setting accompanied by assays (S276) or real-time feedback, or by means of a wearable device that, based on feedback, regulates USMD in real time. Optionally, the user is provided an indication (S281) as to progress or success, of a treatment. Electrodes (128) may be attached across tissue in which transient pores are produced via sonoporation in the USMD procedure, and in vivo measurement is taken of an electrical parameter responsive to permeability. Therapeutic agent (S202) may be administered after particles activated for sonoporation are cleared from the circulation, to avoid, when it might exist, adverse interaction between the particles and agent.
3 Citations
23 Claims
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1. A device comprising:
an ultrasound therapy module (112) configured for, automatically and without need for user intervention, performing ultrasound mediated delivery so as to deliver a therapeutic agent via pressure-mediated, rather than temperature-mediated, effects, said device being configured for, automatically and without need for user intervention, proceeding based on quantitative feedback derived from the delivering. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A device comprising:
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an ultrasound therapy module configured for, automatically and without need for user intervention, performing ultrasound mediated delivery of a therapeutic agent; a processor configured for, automatically and without need for user intervention, deriving, in real time, quantitative feedback; and electrodes (128) attachable to, following production of transient pores, perform said deriving, said deriving comprising taking in vivo measurement, across said pores, of an electrical parameter indicative of permeability. - View Dependent Claims (13)
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14. A method comprising:
based on quantitative feedback (S276), repeating or continuing ultrasound mediated delivery that is based on pressure-mediated, rather than temperature-mediated, effects. - View Dependent Claims (15, 16)
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17. A wearable device comprising:
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an ultrasound mediated delivery module (315) for applying ultrasound to particles to deliver, as a payload, a therapeutic agent; and a unit (320) configured for, automatically and without need for user intervention, both sampling body fluid and analyzing the samples. - View Dependent Claims (18)
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19. A method for ultrasound mediated delivery for which quantitative feedback is derived, comprising, in either order:
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producing (S240) a transient pore through which to, by said delivery, deliver a therapeutic agent; and attaching electrodes to, following said producing and in performing the deriving, take in vivo measurement of an electrical parameter responsive to permeability. - View Dependent Claims (20)
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21. A device configured for ultrasound mediated delivery;
- for applying energy to produce a transient pore through which to perform said delivery; and
, for, after the pore is produced, administering said agent for said delivery through said pore (S252). - View Dependent Claims (22)
- for applying energy to produce a transient pore through which to perform said delivery; and
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23. A computer readable medium for a substance delivery device, said medium comprising instructions executable by a processor for carrying out a series of acts, among which are the acts of, automatically and without need for user intervention:
- a) performing ultrasound mediated delivery so as to deliver a therapeutic agent via pressure-mediated, rather than temperature-mediated, effects (S234);
b) deriving (S264), in real time, quantitative feedback; and
c) proceeding based on the derived feedback.
- a) performing ultrasound mediated delivery so as to deliver a therapeutic agent via pressure-mediated, rather than temperature-mediated, effects (S234);
Specification