Method for lightening or eradicating pigments in human skin

• US 20140243804A1
• Filed: 02/28/2013
• Published: 08/28/2014
• Est. Priority Date: 02/28/2013
• Status: Active Grant

• Current Assignee: Fotona D.O.O. (Fotona Holdings LLC)
• Original Assignee: Fotona d.d. (Fotona Holdings LLC)
• Inventors: Lukac, Matjaz, Vizintin, Zdenko
• Granted Patent: US 9,254,174 B2
• Time in Patent Office: Days
• US Class Current: 606/9
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2018/0047 Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
• CPC Class Codes: A61B 2018/00577 Ablation

Abstract

For lightening or eradicating pigments in human skin, a first conditioning laser optical energy having first optical parameters selected to obtain an ablative effect on the epidermal layer of human skin is provided. A target area of the human skin is conditioned by directing the first conditioning laser optical energy onto the target area and forming in an epidermal layer of the target area discrete pressure and gas release ducts across the target area. A second treatment laser optical energy is provided that has second optical parameters selected to obtain a lightening or eradicating effect on the pigments located within the human skin and to substantially avoid damaging the epidermal layer of the human skin. The second treatment laser optical energy is directed onto the target area subsequent to conditioning, and the pigments within the human skin are lightenmed or eradicated by the second treatment laser optical energy.

Claims

1. A method for lightening or eradicating pigments in human skin, the method comprising;

providing a first conditioning laser optical energy having first optical parameters selected to obtain an ablative effect on the epidermal layer of human skin,

conditioning a target area of the human skin by directing the first conditioning laser optical energy onto the target area and forming in an epidermal layer of the target area a plurality of discrete pressure and gas release ducts distributed across the target area;

providing a second treatment laser optical energy having second optical parameters selected to obtain a lightening or eradicating, effect on the pigments located within the human skin and to substantially avoid damaging, the epidermal layer of the human skin;

subsequent to the step of conditioning, directing the second treatment laser optical energy onto the target area and lightening or eradicating the pigments within the human skin by the second treatment laser optical energy.

2. The method of claim 1, wherein the discrete pressure and gas release ducts are formed with a depth in a range of 30 micrometers to 3,000 micrometers.

3. The method of claim 1, wherein the discrete pressure and gas release ducts are formed with a depth in a range of 50 micrometers to 300 micrometers.

4. The method of claim 1, wherein the discrete pressure and gas release ducts that are immediately neighboring each other are separated from each other by a distance in a range of 100 micrometers to 2,000 micrometers.

5. The method of claim 1, wherein the discrete pressure and gas release ducts that are immediately neighboring each other are separated from each other by a distance in a range of 200 micrometers to 900 micrometers.

6. The method of claim 1, wherein the discrete pressure and gas release ducts have a diameter in a range from 50 micrometers to 1,000 micrometers.

7. The method of claim 1, wherein the step of conditioning includes focusing with an array of focusing elements the first conditioning laser optical energy substantially simultaneously onto a plurality of discrete ablation zones to form the discrete pressure and gas release ducts.

8. The method of claim 1, wherein the step of conditioning, includes focusing with a diffraction element the first conditioning laser optical energy substantially simultaneously onto a plurality of discrete ablation zones to form the discrete pressure and gas release ducts.

9. The method of claim 1, wherein the step of conditioning includes scanning with a scanner coupled to a focusing element the first conditioning optical laser energy across the target area to form the discrete pressure and gas release ducts.

10. The method of claim 1, wherein the step of conditioning includes delivering the first conditioning optical energy to the target area as a temporal pulse train comprising individual single pulses that follow each other in a pulse repetition time shorter than 300.0 ms.

11. The method of claim 1, wherein the step of directing includes applying the second treatment laser optical energy with a beam cross-sectional area covering multiple discrete pressure and gas release ducts on the target area.

12. The method of claim 11, wherein the beam cross-sectional area a mean diameter in a range from 3 mm to 15 mm has on the target area.

13. The method of claim 1, further comprising the step of generating the second treatment laser optical energy with an ESP laser source having a pigment-absorbed wavelength in a range from 0.4 micrometers to 1.1 micrometers.

14. The method of claim 13, wherein the ESP laser source is selected from the group consisting of a Q-switched Nd:

YAG laser source having a wavelength of 1,064 nm;

a frequency-doubled Q-switched Nd;

YAG laser source having a wavelength of 532 nm;

a dye laser source with a wavelength of 580 nm;

a dye laser source with a wavelength of 650 nm;

a ruby laser source having a wavelength of 694 nm; and

an alexandrite laser source having a wavelength of 755 nm.

15. The method of claim 13, wherein the step of directing includes delivering the second treatment laser optical energy to the target area in a single treatment pulse or in 2 to 5 consecutive treatment pulses (p₂).

16. The method of claim 15, wherein the treatment pulses each have on the target area a fluence in a range from 3 J/cm²to 10 J/cm².

17. The method of claim 15, wherein the treatment pulses each have a pulse duration in a range from 0.5 nanoseconds to 100 nanoseconds.

18. The method of claim 15, wherein the treatment pulses each have a pulse duration in a range from 0.5 nanoseconds to 25 nanoseconds.

19. The method of claim 13, wherein both the first conditioning laser optical energy and the second treatment laser optical energy are generated by the same ESP laser source.

20. The method of claim 19, wherein the first conditioning laser optical energy is delivered, to the target area in a single conditioning pulse or in 2 to 10 consecutive conditioning pulses.

21. The method of claim 20, wherein the conditioning pulses each have on the target area a fluence in a range from 30 J/cm² to 350 J/cm².

22. The method of claim 20, wherein the conditioning pulses each have a pulse duration in a range from 0.5 nanoseconds to 100 nanoseconds.

23. The method of claim 20, wherein the conditioning pulses each have a pulse duration in a range from 0.5 nanoseconds to 25 nanoseconds.

24. The method of claim 1, wherein the step of conditioning includes generating the first conditioning laser optical energy with a laser source having a water-absorbed wavelength in a range from 2 micrometers to 11 micrometers.

25. The method of claim 24, wherein the laser source is selected from the group consisting of an Er:

YAG laser source having a wavelength of 2,940 nm;

an Er;

YSGG laser source having a wavelength of 2,790 nm;

an Er,Cr;

YSGG laser source having a wavelength of 2,780 nm; and

an CO₂ laser source having a wavelength of 9,600 to 10,600 nm.

26. The method of claim 24, wherein the step of conditioning includes delivering the first conditioning laser optical energy to the target area in a single conditioning pulse or in 2 to 100 consecutive conditioning pulses.

27. The method of claim 26, wherein a cumulative delivered fluence on the target area of all of the conditioning pulses is in a range of 7.5 J/cm² to 750 J/cm²

28. The method of claim 26, wherein the conditioning pulses have a pulse duration in a range from 10 microseconds to 2,000 microseconds.