DRUG DELIVERY BY CARBON NANOTUBE ARRAYS

• US 20140248216A1
• Filed: 11/20/2013
• Published: 09/04/2014
• Est. Priority Date: 09/02/2010
• Status: Abandoned Application

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Gharib, Morteza, Aria, Adrianus Indrat, Beizai, Masoud
• Application Number:
  US14/085,235
• Publication Number:
  US 20140248216A1
• Time in Patent Office: Days
• US Class Current: 424/9.2
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/6929 the form being a nanoparticle, e.g. an immuno-nanoparticle
• CPC Class Codes: A61K 49/0004 Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
• CPC Class Codes: A61K 49/0095 Nanotubes
• CPC Class Codes: A61K 9/5192 Processes
• CPC Class Codes: A61L 2300/422 Anti-atherosclerotic agents
• CPC Class Codes: A61L 29/103 Carbon
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: B82Y 40/00 Manufacture or treatment of nanostructures
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The invention generally relates to carbon nanotube based drug delivery methods, devices, and compositions. More particularly, the invention relates to controlled drug delivery using anchored carbon nanotube arrays.

Claims

1. The method of claim 1, wherein depositing the agent to the plurality of carbon nanotubes comprises:

(i) mixing the agent in a low surface tension solvent forming a solution of the agent;

(ii) coating the plurality of carbon nanotubes with the solution of the agent; and

(iii) drying the coated plurality of carbon nanotubes, thereby removing the solvent while leaving the agent associated with the plurality of carbon nano tubes.

2. The method of claim 1, wherein the low surface tension solvent is an alcohol.

3. The method of claim 2, wherein the alcohol is ethanol.

4. An implantable drug delivery device, comprising:

(a) an implantable device;

(b) an array of carbon nanotubes anchored on the implantable device; and

(c) an agent deposited on the array of carbon nanotubes, wherein the agent is not covalently bound to the carbon nanotubes.

5. The implantable drug delivery device of claim 4, wherein the agent is a pharmaceutical agent capable of providing a therapeutic effect.

6. The implantable drug delivery device of claim 4, wherein the agent is a diagnostic agent capable of providing a detectable signal or image indicating a biologically relevant state of the subject.

7. The implantable drug delivery device of claim 4, wherein the agent comprises an aromatic moiety.

8. A method for monitoring in situ delivery of an agent, comprising:

(a) providing a plurality of carbon nanotubes non-covalently associated thereon a pharmaceutical agent and a second agent capable of exhibiting a spatially detectable signal;

(b) placing the plurality of carbon nanotubes at a target location in the patient'"'"'s body; and

(c) measuring the detectable signal exhibited from the second agent to monitor the deliver of the pharmaceutical agent in situ.

9. The method of claim 8, wherein the agent is a pharmaceutical agent comprises an aromatic moiety.