LYSINE DEMETHYLASE INHIBITORS FOR DISEASES AND DISORDERS ASSOCIATED WITH FLAVIVIRIDAE
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Abstract
The invention relates to methods and compositions for the treatment or prevention of Flaviviridae infections. In particular, the invention relates to an LSD1 inhibitor for use in treating or preventing Flaviviridae infections, including hepatitis C virus infections.
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Citations
94 Claims
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1-27. -27. (canceled)
- 28. A method of treating or preventing a Flaviviridae infection or a disease or disorder associated with Flaviviridae comprising identifying an individual in need of such treatment and administering to said individual a LSD1 inhibitor.
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30. (canceled)
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35-47. -47. (canceled)
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48. A method of treating or preventing a symptom of Hepatitis C virus infection or a liver disease in an individual infected with Hepatitis C virus, the method comprising identifying an individual in need of such treatment and administering to said individual an LSD1 inhibitor.
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49. (canceled)
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50. A method of treating or preventing HCV and HBV co-infection comprising identifying an individual in need of such treatment and administering to said individual an LSD1 inhibitor and optionally a second anti-HCV agent or anti-HBV agent.
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53-54. -54. (canceled)
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57. (canceled)
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59-66. -66. (canceled)
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68-69. -69. (canceled)
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71. The method of claim, wherein the cyclyl moiety in said -L2-cyclyl is heteroaryl or heterocycloalkyl.
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72-74. -74. (canceled)
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76-82. -82. (canceled)
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85-92. -92. (canceled)
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94-109. -109. (canceled)
Specification