FORMULATIONS FOR DRUG-COATED MEDICAL DEVICES
First Claim
1. An angioplasty balloon catheter characterized by a catheter shaft having an inflatable balloon at its distal end and a constraining structure constraining the expansion of the inflatable balloon, said constraining structure having a non-expanded configuration prior to inflation and an expanded configuration which is smaller than an unconstrained size of the balloon so that the structure restrains the balloon inflation along a plurality of crossing channel lines, carrying at least on a portion of its surface a taxane or a polymer-free taxane preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one antioxidant in relation to 100% by weight of the taxane, wherein the at least one lipophilic antioxidant is selected of propyl gallate, nordihydroguaiarectic acid, or resveratrol, wherein scoring or cutting balloons as medical devices are excluded.
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Accused Products
Abstract
The invention relates to an angioplasty catheter having a balloon and a constraining element carrying at least on a portion of its surface a taxane or taxane preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one antioxidant in relation to 100% by weight of the taxane, wherein a preferred lipophilic antioxidant is propyl gallate. Scoring or cutting balloons as medical devices are excluded.
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Citations
9 Claims
- 1. An angioplasty balloon catheter characterized by a catheter shaft having an inflatable balloon at its distal end and a constraining structure constraining the expansion of the inflatable balloon, said constraining structure having a non-expanded configuration prior to inflation and an expanded configuration which is smaller than an unconstrained size of the balloon so that the structure restrains the balloon inflation along a plurality of crossing channel lines, carrying at least on a portion of its surface a taxane or a polymer-free taxane preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one antioxidant in relation to 100% by weight of the taxane, wherein the at least one lipophilic antioxidant is selected of propyl gallate, nordihydroguaiarectic acid, or resveratrol, wherein scoring or cutting balloons as medical devices are excluded.
Specification