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METHODS FOR INHIBITING STENOSIS, OBSTRUCTION, OR CALCIFICATION OF A STENTED HEART VALVE OR BIOPROSTHESIS

  • US 20140257473A1
  • Filed: 04/28/2014
  • Published: 09/11/2014
  • Est. Priority Date: 10/22/2012
  • Status: Abandoned Application
First Claim
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1. A method for inhibiting stenosis, obstruction, or calcification of a bioprosthetic valve following implantation of said bioprosthetic valve in a vessel having a wall, said method comprising:

  • providing a bioprosthetic valve for surgical replacement of a natural diseased valve, said bioprothestic value including an elastical stent;

    providing a coating composition on said elastical stent, bioprosthetic valve or both, wherein the coating composition comprises one or more therapeutic agents;

    implanting said bioprosthetic valve into said vessel by surgically removing a natural valve and replacing said natural valve with said bioprosthesis or placing said bioprosthesis over said natural valve having valve leaflets thereby compressing said natural valve leaflets against the vessel wall;

    eluting said therapeutic agents from said elastical stent, bioprosthetic valve or both; and

    causing the inhibition of stenosis, obstruction, or calcification of the bioprosthesis or the natural valve or both following implantation of the bioprosthetic valve.

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