METHODS FOR INHIBITING STENOSIS, OBSTRUCTION, OR CALCIFICATION OF A STENTED HEART VALVE OR BIOPROSTHESIS
First Claim
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1. A method for inhibiting stenosis, obstruction, or calcification of a bioprosthetic valve following implantation of said bioprosthetic valve in a vessel having a wall, said method comprising:
- providing a bioprosthetic valve for surgical replacement of a natural diseased valve, said bioprothestic value including an elastical stent;
providing a coating composition on said elastical stent, bioprosthetic valve or both, wherein the coating composition comprises one or more therapeutic agents;
implanting said bioprosthetic valve into said vessel by surgically removing a natural valve and replacing said natural valve with said bioprosthesis or placing said bioprosthesis over said natural valve having valve leaflets thereby compressing said natural valve leaflets against the vessel wall;
eluting said therapeutic agents from said elastical stent, bioprosthetic valve or both; and
causing the inhibition of stenosis, obstruction, or calcification of the bioprosthesis or the natural valve or both following implantation of the bioprosthetic valve.
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Abstract
The present invention relates to methods for inhibiting stenosis, obstruction, or calcification of a valve following implantation of a valve prosthesis which may involve disposing a coating composition on an elastical stent or valve leaflet. The valve prosthesis is mounted on the elastical stent such that the elastical stent is in contact with the valve.
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Citations
34 Claims
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1. A method for inhibiting stenosis, obstruction, or calcification of a bioprosthetic valve following implantation of said bioprosthetic valve in a vessel having a wall, said method comprising:
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providing a bioprosthetic valve for surgical replacement of a natural diseased valve, said bioprothestic value including an elastical stent; providing a coating composition on said elastical stent, bioprosthetic valve or both, wherein the coating composition comprises one or more therapeutic agents; implanting said bioprosthetic valve into said vessel by surgically removing a natural valve and replacing said natural valve with said bioprosthesis or placing said bioprosthesis over said natural valve having valve leaflets thereby compressing said natural valve leaflets against the vessel wall; eluting said therapeutic agents from said elastical stent, bioprosthetic valve or both; and causing the inhibition of stenosis, obstruction, or calcification of the bioprosthesis or the natural valve or both following implantation of the bioprosthetic valve. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 24, 26, 33)
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13. The method according to clause 12, wherein the diameter of the elastical stent is about 15 mm to about 42 mm.
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14. A valve prosthesis comprising:
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an elastical stent; a bioprosthetic valve having leaflets operably coupled to said elastical stent; a therapeutic agent on the elastical stent, bioprosthetic valve on sides of the leaflets or both, said therapeutic agent structured to elute from said elastical stent, bioprosthetic valve leaflets or both; wherein said bioprosthetic valve is structured to be implanted in vessel having a vessel wall to replace a natural diseased valve; said bioprosthetic valve structured to inhibit stenosis, obstruction, or calcification of the bioprosthetic valve and natural valve following implantation of the bioprosthetic valve prosthesis. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 25, 27, 28, 29, 30, 31, 32, 34)
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23. The valve prosthesis of clause 14 wherein a diameter of the elastical stent is about 15 mm to about 42 mm.
Specification