Novel Simulation and Permutation Methods for the Determination of Temporal Association between Two Events
First Claim
1. A method for determining an association between two types of health events during a tested association window size in a patient, using a computer readable medium configured to execute steps comprising:
- determining data related to a timing of and a number of occurrences of a first type of health event;
determining data related to a timing of and number of occurrence of a second type of health event;
computing a value for a symptom index for the first type of health event and the second type of health event using a fraction of the number of occurrences of events of the second type occurring within the tested association window size following an event of the first type compared to the total number of events of the second type;
computing a value for a symptom sensitivity index similarly by using a fraction of the number of occurrences of events of the first type occurring within the tested association window size preceding an event of the second type compared to the total number of events of the second type;
using the symptom index value, the symptom sensitivity index value, and a p-value of the symptom index and symptom sensitivity index obtained in simulation and permutation data to determine whether there is an association between the first type of event and the second type of event; and
determining a care and treatment plan for the patient based on whether there is an association between the first type of event and the second type of event.
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Abstract
An embodiment in accordance with the present invention provides methods and software for determining an association between two health events, temporally. The methods can be implemented on a computing device either individually, or as a group, and are noted as simulation, permutation shuffling, and permutation sliding. Simulation, permutation shuffling, and permutation sliding each use the comparison of the experimentally found occurrence of association between the two health events to the null distribution of the association statistics, obtained by independently simulating the two health events. In particular, these methods of determining association between two health events can be used for determining an association between reflux and apnea in infants. However, these methods can also be applied more generally to determining a potential relationship between health or other events in the temporal plane.
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Citations
15 Claims
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1. A method for determining an association between two types of health events during a tested association window size in a patient, using a computer readable medium configured to execute steps comprising:
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determining data related to a timing of and a number of occurrences of a first type of health event; determining data related to a timing of and number of occurrence of a second type of health event; computing a value for a symptom index for the first type of health event and the second type of health event using a fraction of the number of occurrences of events of the second type occurring within the tested association window size following an event of the first type compared to the total number of events of the second type; computing a value for a symptom sensitivity index similarly by using a fraction of the number of occurrences of events of the first type occurring within the tested association window size preceding an event of the second type compared to the total number of events of the second type; using the symptom index value, the symptom sensitivity index value, and a p-value of the symptom index and symptom sensitivity index obtained in simulation and permutation data to determine whether there is an association between the first type of event and the second type of event; and determining a care and treatment plan for the patient based on whether there is an association between the first type of event and the second type of event. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for determining an association between two health events in a patient, using a computer readable medium configured to execute steps comprising:
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determining data related to a length of time between occurrences of a first type of health event; determining data related to a length of time between occurrences of a second type of health event; computing a value for a symptom index for the first type of health event and the second type of health event using the length of time between occurrences of the first type of health event and the length of time between occurrences of the second type of health event; computing a value for a symptom sensitive index for the first type of health event and the second type of health event using the length of time between occurrences of the first type of health event and the length of time between occurrences of the second type of health event; using the symptom index value, the symptom sensitive index value, and a p-value obtained with permutation methods to determine whether there is an association between the first type of event and the second type of event; and determining a care and treatment plan for the patient based on whether there is an association between the first type of event and the second type of event. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15)
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Specification