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Novel Simulation and Permutation Methods for the Determination of Temporal Association between Two Events

  • US 20140258306A1
  • Filed: 10/12/2012
  • Published: 09/11/2014
  • Est. Priority Date: 10/12/2011
  • Status: Abandoned Application
First Claim
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1. A method for determining an association between two types of health events during a tested association window size in a patient, using a computer readable medium configured to execute steps comprising:

  • determining data related to a timing of and a number of occurrences of a first type of health event;

    determining data related to a timing of and number of occurrence of a second type of health event;

    computing a value for a symptom index for the first type of health event and the second type of health event using a fraction of the number of occurrences of events of the second type occurring within the tested association window size following an event of the first type compared to the total number of events of the second type;

    computing a value for a symptom sensitivity index similarly by using a fraction of the number of occurrences of events of the first type occurring within the tested association window size preceding an event of the second type compared to the total number of events of the second type;

    using the symptom index value, the symptom sensitivity index value, and a p-value of the symptom index and symptom sensitivity index obtained in simulation and permutation data to determine whether there is an association between the first type of event and the second type of event; and

    determining a care and treatment plan for the patient based on whether there is an association between the first type of event and the second type of event.

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