Cannulas, Collars for Implantable Devices, and Corresponding Systems and Methods
First Claim
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1. An implantable device with a layer of dehydrated basement membrane formed thereon, the basement membrane layer comprising at least one member selected from the group consisting of sleeve-shaped coatings for cannulas, collars for cannulas, and collars for sensors.
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Abstract
Disclosed herein is implantable device with a layer of dehydrated basement membrane formed thereon, the implantable device comprising at least one member selected from the group consisting of cannulas, collars for cannulas, and collars for sensors. Methods of making and using the extended use device also are disclosed.
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Citations
18 Claims
- 1. An implantable device with a layer of dehydrated basement membrane formed thereon, the basement membrane layer comprising at least one member selected from the group consisting of sleeve-shaped coatings for cannulas, collars for cannulas, and collars for sensors.
- 10. An implantable device having a collar configured to be disposed at an interface between tissue and the implantable device, the collar being formed from an extracellular matrix.
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14. A method comprising:
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obtaining an implantable device comprising at least one member selected from the group consisting of cannulas and sensors, placing basement membrane in the form of a liquid or gel on the implantable device to form at least one of a sleeve and a collar on the device, and dehydrating the basement membrane on the implantable device. - View Dependent Claims (15)
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16. The method of claim 16, wherein the basement membrane contains adenovirus vectors containing a VEGF gene.
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18. A method of increasing by at least 10 days the lifespan of an implantable device comprising at least one member selected from the group consisting of cannulas and sensors inserted in a mammal, comprising forming an extracellular matrix coating around a portion of the implantable device in the form of a sleeve or a collar, the coating comprising dehydrated extracellular matrix which is rehydrated after implantation, the extracellular matrix having cells and/or factors attached thereto using fibronectin.
Specification