Use of Antibiotics to Enhance Treatment With Therapeutic Viruses
First Claim
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1. A method for enhancing the effectiveness of a therapeutic virus, comprising administering an antibiotic with, before, after or during treatment with the therapeutic virus, to inhibit the growth of or kill commensal gut bacteria to thereby reduce the number of gut bacteria, wherein:
- the antibiotic is an antibiotic that inhibits the growth of or kills commensal gut bacteria and is not an anti-cancer antibiotic; and
the antibiotic is administered in an amount that reduces or eliminates commensal gut bacteria.
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Abstract
Provided are methods for increasing the therapeutic efficacy of viral therapy by administering an antibiotic effective against commensal bacteria with the viral therapy. Included are methods for treating cancers, tumors and metastases by administering the virus and the antibiotic.
19 Citations
47 Claims
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1. A method for enhancing the effectiveness of a therapeutic virus, comprising administering an antibiotic with, before, after or during treatment with the therapeutic virus, to inhibit the growth of or kill commensal gut bacteria to thereby reduce the number of gut bacteria, wherein:
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the antibiotic is an antibiotic that inhibits the growth of or kills commensal gut bacteria and is not an anti-cancer antibiotic; and the antibiotic is administered in an amount that reduces or eliminates commensal gut bacteria. - View Dependent Claims (2, 3, 4, 5, 6, 13)
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7. A method for treating cancers or tumors, comprising:
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administering a therapeutic virus for treatment of cancers, tumors or metastases, wherein the therapeutic virus is effective for treating one or more of cancers, tumors or metastases; and administering an antibiotic that is effective against commensal gut bacteria, wherein; the antibiotic is administered before, after or with the therapeutic virus; and the antibiotic is administered in an amount that reduces or eliminates commensal gut bacteria. - View Dependent Claims (8, 9, 10, 11, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A combination, comprising:
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a first composition, comprising a therapeutic virus in a pharmaceutically acceptable vehicle, and a second composition, comprising an antibiotic in a pharmaceutically acceptable vehicle, wherein the antibiotic inhibits the growth of or kills commensal gut bacteria to thereby reduce the number of gut bacteria and is not an anti-cancer antibiotic. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47)
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Specification