MEMORY OR LEARNING USING PEPTIDE AND OTHER COMPOSITIONS

• US 20140271806A1
• Filed: 03/13/2013
• Published: 09/18/2014
• Est. Priority Date: 03/13/2013
• Status: Active Grant

• Current Assignee: Transdermal Biotechnology, Inc.
• Original Assignee: Transdermal Biotechnology, Inc.
• Inventors: Perricone, Nicholas V.
• Granted Patent: US 9,687,520 B2
• Time in Patent Office: Days
• US Class Current: 424/450
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 38/066 TRH, thyroliberin, thyrotropin releasing hormone
• CPC Class Codes: A61K 38/095 Oxytocins; Vasopressins; Related peptides
• CPC Class Codes: A61K 38/34 Melanocyte stimulating hormone [MSH], e.g. alpha- or beta-melanotropin
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/127 Liposomes
• CPC Class Codes: A61K 9/1274 Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases

Abstract

The present invention generally relates to compositions and methods for topical or transdermal delivery, including treatment and prevention of learning and memory disorders, and enhancement of learning or memory. In some cases, the composition may include nitric oxide, peptides, or both. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide and/or peptide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

Claims

1. A method, comprising:

administering, to the skin of a subject to improve the subject'"'"'s memory or learning, a composition comprising an effective amount of a peptide and molecular nitric oxide to improve the subject'"'"'s memory or learning, and a carrier having a phosphatidylcholine component entrapping the molecular nitric oxide, wherein the molecular nitric oxide is present within the carrier as a gas or bound by hydrogen bonds or van der Waals forces.

2. The method of claim 1, wherein the peptide comprises thyrotropin-releasing hormone (TRH).

3. The method of claim 1, wherein the peptide comprises melanocyte-stimulating hormone (MSH).

4. The method of claim 1, wherein the peptide comprises vasopressin.

5. The method of claim 1, wherein the phosphatidylcholine carrier stabilizes the nitric oxide at a temperature at or lower than 80°

C.

9. The method of claim 1, wherein the composition comprises a liquid crystal structure comprising the phosphatidylcholine.

10. The method of claim 9, wherein at least a portion of the liquid crystal structure is multilamellar.

6-8. -8. (canceled)

11. A method, comprising contacting the skin of a subject to improve the subject'"'"'s memory or learning with a composition comprising:

an emulsion comprising a first phase comprising a peptide, molecular nitric oxide, and lecithin, and a second phase comprising an emulsifier, wherein the lecithin is present at least about 0.25% by weight of the composition, wherein the first phase comprises no more than about 250 ppm of water by weight of the composition, and wherein the molecular nitric oxide is present within the emulsion as a gas or bound by hydrogen bonds or van der Waals forces to the lecithin.

12. The method of claim 11, wherein the peptide comprises thyrotropin-releasing hormone (TRH).

13. The method of claim 11, wherein the peptide comprises melanocyte-stimulating hormone (MSH).

14. The method of claim 11, wherein the peptide comprises vasopressin.

15. The method of claim 11, wherein the first phase forms discrete vesicles contained within the second phase.

16. The method of claim 15, wherein the first phase forms liposomes contained within the second phase.

17. The method of claim 15, wherein the first phase forms multilamellar liposomes contained within the second phase.

20. The method of claim 11, wherein the nitric oxide is present at at least about 0.5% by weight of the composition without nitric oxide.

28. The method of claim 11, wherein the lecithin comprises a phosphatidylcholine.

32. The method of claim 28, wherein at least some of the phosphatidylcholine comprises a polyenylphosphatidylcholine.

38. The method of claim 11, wherein the first phase comprises a fatty acid ester.

43. The method of claim 11, wherein the composition is a gel.

44. The method of claim 11, wherein the composition is a cream.

18-19. -19. (canceled)

21-27. -27. (canceled)

29-31. -31. (canceled)

33-37. -37. (canceled)

39-42. -42. (canceled)

45-47. -47. (canceled)

48. A method, comprising:

administering, topically to the skin of a subject, a composition comprising an effective amount of thyrotropin-releasing hormone (TRH) to improve the subject'"'"'s memory or learning.

49. The method of claim 48, wherein the composition comprises phosphatidylcholine.

50. The method of claim 49, wherein the composition comprises a liquid crystal structure comprising the phosphatidylcholine.

51. The method of claim 50, wherein at least a portion of the liquid crystal structure is multilamellar.

52. The method of claim 49, wherein at least some of the phosphatidylcholine comprises a polyenylphosphatidylcholine.

53. The method of claim 48, wherein the composition is a cream, a gel, a lotion, or an ointment.