INHIBITION OF HYPOXIA-INDUCIBLE FACTOR ACTIVITY WITH CARICA PAPAYA EXTRACTS
First Claim
1. A method is provided for treating a hypoxia-related condition or in a patient, comprising the steps of:
- identifying a patient with a hypoxia-related condition having hypoxia-inducible factors, andadministering to the patient a therapeutically acceptable amount of an extract of Carica papaya leaves obtained from a plant of age six months and younger from the date of germination of the seed,whereby to inhibit the hypoxia-inducible factors.
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Accused Products
Abstract
An extract of Carica papaya leaves obtained from a plant of age six months and younger from the date of germination of the seed is used as an inhibitor of HIF to effectively block hypoxia-inducible factor (HIF) function and methods of use thereof. More specifically it relates to the use of the Carica papaya plant extract to eliminate unwanted cells by inhibiting HIF in the prevention and treatment of hypoxia-related conditions and diseases such as inflammatory diseases, vascular diseases, cancer and infectious diseases. In a particular embodiment, a solid hypoxic tumor in a patient is treated by administering to the patient a therapeutically acceptable amount of an extract of Carica papaya leaves obtained from a plant of age six months and younger from the date of germination of the seed, preferably an alcohol extract such as a methanol extract, whereby to inhibit hypoxia-inducible factors in the tumor.
5 Citations
13 Claims
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1. A method is provided for treating a hypoxia-related condition or in a patient, comprising the steps of:
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identifying a patient with a hypoxia-related condition having hypoxia-inducible factors, and administering to the patient a therapeutically acceptable amount of an extract of Carica papaya leaves obtained from a plant of age six months and younger from the date of germination of the seed, whereby to inhibit the hypoxia-inducible factors. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A composition of matter comprising an alcohol extraction from Carica papaya leaves obtained from a plant of age six months and younger from the date of germination of the seed.
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13. An article of manufacture comprising packaging material and contained within the packaging material, an extract of Carica papaya leaves obtained from a plant of age six months and younger from the date of germination of the seed wherein the packaging material comprises instructions for use of the extract for treating a solid hypoxic tumor.
Specification