SUBSTANTIALLY SURFACTANT-FREE, SUBMICRON DISPERSIONS OF HYDROPHOBIC AGENTS CONTAINING HIGH LEVELS OF WATER MISCIBLE SOLVENT

• US 20140271877A1
• Filed: 03/14/2014
• Published: 09/18/2014
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Leading Edge Innovations, Llc
• Original Assignee: Leading Edge Innovations, Llc
• Inventors: Wilmott, James Michael, Ross, Michael Alan
• Granted Patent: US 9,357,770 B2
• Time in Patent Office: Days
• US Class Current: 424/489
• CPC Class Codes: A01N 25/04 Dispersions, emulsions, suspoemulsions, suspension concentrates or gels foams A01N25/16
• CPC Class Codes: A01N 31/08 Oxygen or sulfur directly attached to an aromatic ring system
• CPC Class Codes: A01N 55/00 Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing organo-phosphorus compounds A01N57/00
• CPC Class Codes: A01N 65/08 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 2800/244 Endothermic; Cooling; Cooling sensation
• CPC Class Codes: A61K 2800/28 Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
• CPC Class Codes: A61K 2800/33 Free of surfactant
• CPC Class Codes: A61K 2800/413 Nanosized, i.e. having sizes below 100 nm
• CPC Class Codes: A61K 2800/48 Thickener, Thickening system
• CPC Class Codes: A61K 8/0212 Face masks
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/04 Dispersions; Emulsions
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/25 Silicon; Compounds thereof
• CPC Class Codes: A61K 8/345 containing more than one hydroxy group
• CPC Class Codes: A61K 8/4946 Imidazoles or their condensed derivatives, e.g. benzimidazoles
• CPC Class Codes: A61K 8/73 Polysaccharides
• CPC Class Codes: A61K 8/8152 Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/891 saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
• CPC Class Codes: A61K 8/922 of vegetable origin
• CPC Class Codes: A61Q 13/00 : Formulations or additives for perfume preparations essential oils or perfumes per se C11B9/00
• CPC Class Codes: A61Q 17/005 : Antimicrobial preparations
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: A61Q 19/007 : Preparations for dry skin
• CPC Class Codes: A61Q 19/10 : Washing or bathing preparations
• CPC Class Codes: A61Q 9/02 : Shaving preparations
• CPC Class Codes: Y10S 977/773 : Nanoparticle, i.e. structure having three dimensions of 100 nm or less
• CPC Class Codes: Y10S 977/906 : Drug delivery

Abstract

A composition is provided to apply to the skin, hair, or external mucosa of a human or animal, and a method for using the composition. The composition includes for example a composition for application to skin, hair or external mucosa comprising: a) dispersed submicron particles of hydrophobic agent(s) having average particle size from 100 nm to 999 nm; b) an aqueous-solvent fluid; and c) rheological modifying agent(s); wherein the aqueous-solvent fluid is 10% to 95% wt. of one or more water miscible solvent(s), 4.99% to 89.99% wt. water, and 0.01% to 10% wt. of the rheological modifying agent(s); and wherein the hydrophobic agents comprise 0.01 to 70% wt. of the skin, hair or mucosal composition; and wherein the composition is substantially surfactant-free.

Claims

1. A composition for application to skin, hair or external mucosa comprising:

a) dispersed submicron particles of hydrophobic agent(s) having average particle size from 100 nm to 999 nm;

b) an aqueous-solvent fluid; and

c) rheological modifying agent(s);

wherein the aqueous-solvent fluid is

10% to 95% wt. of one or more water miscible solvent(s),

4.99% to 89.99% wt. water, and

0.01% to 10% wt. of the rheological modifying agent(s); and

wherein the hydrophobic agents comprise 0.01 to 70% wt. of the skin, hair or mucosal composition; and

wherein the composition is substantially surfactant-free.

2. The composition of claim 1, wherein 80% weight or more of the water miscible solvent is a mono-, di- or poly-hydroxy compound of the formula

3. The composition of claim 1, formulated as a moisturizing hand sanitizer comprising a water miscible solvent that is 50% to 89.99% by volume ethanol or isopropanol.

4. The composition of claim 1, formulated as a cooling cologne.

5. The composition of claim 4, wherein the cooling cologne comprising a water miscible solvent that is 20% to 70% by volume ethanol.

6. The composition of claim 1, formulated as a body lotion.

7. The composition of claim 6, wherein the body lotion comprises 10% to 80% wt. of one or more water miscible solvent(s) that is a mono-, di-, or poly-hydroxy compound of the formula:

8. The composition of claim 1, formulated as an exfoliating mask.

9. The composition of claim 8, comprising 10% to 80% wt. of one or more water miscible solvent(s) that is a mono-, di-, or poly-hydroxy compound of the formula:

10. The composition of claim 1, formulated as a lubricating shaving gel or cream.

11. The composition of claim 1, wherein the composition further comprises one or more therapeutic agent(s), wherein the therapeutic agent(s) can be hydrophobic agent(s).

12. The composition of claim 1, wherein the composition further comprises one or more aesthetic modifying agent(s), wherein the aesthetic modifying agent(s) can be hydrophobic agent(s).

13. The composition of claim 1, wherein the hydrophobic agent(s) in the substantially surfactant-free submicron dispersion of particles of hydrophobic agents is a therapeutic agent, an aesthetic modifying agent, or both.

14. A method of applying one or more therapeutic agent(s) to skin, hair or external mucosa comprising applying to the skin, hair, or external mucosa of a human or animal the composition of claim 1, wherein the composition further comprises an effective amount of the one or more therapeutic agent(s), and wherein the one or more therapeutic agents further comprises one or more hydrophobic agents.

15. A method of imparting a desirable tactile, olfactory, or visual property to a skin, hair, or mucosal surface of a human or animal comprising applying to the skin, hair, or mucosal surface a composition of claim 1, wherein the composition further comprises an effective amount of one or more aesthetic modifying agents, and wherein the one or more aesthetic modifying agents further comprise one or more hydrophobic agent.

16. The composition of claim 1, wherein the hydrophobic agent(s) in the substantially surfactant-free submicron dispersion of particles of hydrophobic agents are a therapeutic agent(s), aesthetic modifying agent(s), or both.

17. The composition of claim 1, wherein the therapeutic agent comprises one or more of anti-acne agents, antimicrobial agents, anti-inflammatory agents, analgesics, anti-erythemal agents, anti-pruritic agents, anti-edemal agents, anti-psoriatic agents, anti-fungal agents, skin protectants, sunscreen agents, vitamins, antioxidants, scavengers, anti-irritants, anti-bacterial agents, antiviral agents, antiaging agents, photoprotection agents, hair growth enhancers, hair growth inhibitors, hair removal agents, antidandruff agents, anti-seborrheic agents, exfoliating agents, wound healing agents, anti-ectoparasitic agents, sebum modulators, immunomodulators, hormones, botanicals, moisturizers, astringents, sensates, antibiotics, anesthetics, steroids, tissue healing substances, tissue regenerating substances, amino acids, peptides, minerals, ceramides, biohyaluronic acids, skin bleaching ingredients, and any combinations of the foregoing.

18. The composition of claim 1, wherein the therapeutic agent comprises one or more sunscreen agents including one or more of ethylhexyl methoxycinnamate, avobenzone, benzophenones, octocrylene, ethylhexyl salicylate, homomethyl salicylate, triethanolamine salicylate, menthyl anthranilate, PABA, octyl dimethyl PABA, 2-ethoxyethyl p-methoxycinnamate, phenylbenzimidazole sulfonic acid, titanium dioxide and zinc oxide.

19. The composition of claim 1, wherein the aesthetic modifying agent comprises one or more of

(a) C2-C26 alkyl substituted with 2-24 hydroxyls, where all of the hydroxyls of the foregoing compounds are independently acylated with a saturated, unsaturated, linear, branched or cyclic C1-C24 alkane;

(b) a compound having the formula C_pH<sub>(2p+2−

q)</sub> where p is an integer greater than or equal to 6 and q is 0 or an even integer no greater than p;

(c) a compound having the formula B;

20. The composition of claim 1, wherein the aesthetic modifying agent comprises silicone which comprises one or more of polysiloxanes, cyclic siloxanes, polyalkylsiloxanes, polyarylsiloxanes, polyalkylarylsiloxanes, polysiloxane gums and polyethersiloxane copolymers.