Dietary Composition and Method for Preventing, Reducing, Alleviating or Treating Idiopathic Vomiting

• US 20140271943A1
• Filed: 03/06/2014
• Published: 09/18/2014
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Mars Incorporated
• Original Assignee: IAMS Company (Mars Incorporated)
• Inventors: Hu, Ping, Lin, Yakang, Park, Jean Soon, Reinsalu, Lori Ann
• Granted Patent: US 10,441,623 B2
• Time in Patent Office: Days
• US Class Current: 424/727
• CPC Class Codes: A61K 36/00 Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines antigens from pollen A61K39/36
• CPC Class Codes: A61K 36/15 Pinaceae (Pine family), e.g. pine or cedar
• CPC Class Codes: A61K 36/16 Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/19 Acanthaceae (Acanthus family)
• CPC Class Codes: A61K 36/23 Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
• CPC Class Codes: A61K 36/28 Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 36/324 Boswellia, e.g. frankincense
• CPC Class Codes: A61K 36/41 Crassulaceae (Stonecrop family)
• CPC Class Codes: A61K 36/45 Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
• CPC Class Codes: A61K 36/47 Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61K 36/484 Glycyrrhiza (licorice)
• CPC Class Codes: A61K 36/53 Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• CPC Class Codes: A61K 36/54 Lauraceae (Laurel family), e.g. cinnamon or sassafras
• CPC Class Codes: A61K 36/55 Linaceae (Flax family), e.g. Linum
• CPC Class Codes: A61K 36/61 Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
• CPC Class Codes: A61K 36/634 Forsythia
• CPC Class Codes: A61K 36/67 Piperaceae (Pepper family), e.g. Jamaican pepper or kava
• CPC Class Codes: A61K 36/708 Rheum (rhubarb)
• CPC Class Codes: A61K 36/718 : Coptis (goldthread)
• CPC Class Codes: A61K 36/736 : Prunus, e.g. plum, cherry, peach, apricot or almond
• CPC Class Codes: A61K 36/752 : Citrus, e.g. lime, orange or lemon
• CPC Class Codes: A61K 36/77 : Sapindaceae (Soapberry family), e.g. lychee or soapberry
• CPC Class Codes: A61K 36/81 : Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
• CPC Class Codes: A61K 36/82 : Theaceae (Tea family), e.g. camellia
• CPC Class Codes: A61K 36/835 : Aquilaria
• CPC Class Codes: A61K 36/87 : Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
• CPC Class Codes: A61K 36/88 : Liliopsida (monocotyledons)
• CPC Class Codes: A61K 36/889 : Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
• CPC Class Codes: A61K 36/9066 : Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
• CPC Class Codes: A61K 36/9068 : Zingiber, e.g. garden ginger
• CPC Class Codes: A61K 45/06 : Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/08 : for nausea, cinetosis or vertigo; Antiemetics
• CPC Class Codes: A61P 1/12 : Antidiarrhoeals
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention relates to compositions containing plant materials or extracts with inhibitory effect on a 5-HT3a and/or NK-1 receptor for preventing or treating idiopathic vomiting.

Claims

1. A dietary composition for preventing or treating idiopathic vomiting in a companion animal, comprising one or more plant materials or extracts thereof in an effective amount for inhibiting a 5-hydroxytryptamine-3a serotonin (5-HT_3a) receptor and/or a neurokinin-1 (NK-1) receptor.

2. The dietary composition of claim 1, wherein said plant materials or extracts have inhibitory effect on the 5-HT_3a receptor and are selected from the group consisting of Leptospermum Scoparium (lemon tea tree) leaf extract, a water-soluble fraction of Melaleuca alternifolia (tea tree) oil, Rheum palmatum (rhubarb), Lavandula angustifolia (lavender tea tree) extract, Fusanus Spicatus (Australian sandalwood) extract, Santalum Album (sandalwood) oil, Evodia Rutaecarpa (evodia) fruit, Coptis chinensis (coptis) rhizome, oils from Wisteria sinensis, Myrtus Communis (myrtle) extract, Prunus serotina (wild cherry) bark, Aquilaria sinensis (Chinese Agarwood) resinous heartwood extract, Zingiber officinale (ginger) root, Calendula officinalis (marigold), Boswellia serrata (boswellia), oil from Boswellia carterii (frankincense oil), Zanthoxylim americanum (prickly ash fruit) extract, Pinus pinaster bark extract, Marrubium vulgare (horehound), Citrus aurantium (bitter orange) fruit, Cinnamomum aromaticum (cinnamon), Vaccinium myrtillus (bilberry) extract, Vaccinium corymbosum (blueberry) leaf extract, Daucus carota (carrot) extract, Anthemis eecutita (chamomile) extract, Curcuma longa (turmeric) extract, Vaccinium macrocarpon (cranberry) extract, Linum usitatissimum (flax) oil powder, Hovenia dulcis (Japanese raisin tree) seed extract, Andrographis paniculata (Andrographis herb) extract, bee pollen extract, Eucalyptus radiata (Australia eucalyptus) extract, Yerba Santa extract, Piper nigrum (black pepper) oil, Ginkgo biloba extract, Capsicum annuum (cayenne) extract, and combinations thereof.

3. The dietary composition of claim 1, wherein said plant materials or extracts have inhibitory effect on the 5-HT3a receptor and comprise a combination selected from the group consisting of:

(a) Curcuma longa (turmeric) and Glycyrrhiza glabra (licorice);

(b) Turmeric, licorice, and ginger;

(c) Turmeric and ginger;

(d) Turmeric and rhubarb; and

(e) Licorice, ginger, and rhubarb.

4. The dietary composition of claim 1, wherein said plant materials or extracts have inhibitory effect on the NK-1 receptor and are selected from the group consisting of Podophyllum peltatum (podophyllin), Rhodiola rosea (rhodiola), Tanacetum parthenium (feverfew), Pinus massoniana (pink bark), Boswellia serrata (boswellia), Dracaena cinnabari (Dragon'"'"'s Blood) extract, Tilia vulgaris (linden), Paullinia cupana (guarana), Uncaria tomemtosa (cat'"'"'s claw), Hypericum perforatum (St. John'"'"'s wort), Camellia sinensis (green tea) extract, Vitis vinifera (grape) extract, Cinnamomum aromaticum (cinnamon) extract, Curcuma longa (turmeric) extract, Fructus Forsythiae (Forysthia fruit) extract, Glycyrrhiza glabra (licorice) extract, Litsea cubeba oil, Melaleuca alternifolia (tea tree) oil, Phyllanthus emblica (amla) extract, and combinations thereof.

5. The dietary composition of claim 1, wherein said plant materials or extracts have inhibitory effect on the NK-1 receptor and comprise the combination of turmeric and licorice.

6. The dietary composition of claim 1, wherein said dietary composition is a pet food comprising from 0.1 ppm to 75,000 ppm of said one or more plant materials or extracts thereof, and wherein said pet food further comprises a source of carbohydrate, a source of protein, and optionally a source of fat.

7. The dietary composition of claim 1, wherein said composition is a pet food supplement that is capable of being fed to the companion animal either separately from or in combination with a pet food, wherein said pet food supplement comprises from 0.1% to 99% of said one or more plant materials or extracts thereof by weight.

19. A kit for preventing or treating idiopathic vomiting in a companion animal, comprising:

(a) a dietary composition according to claim 1; and

(b) instructions for feeding said companion animal with the dietary composition, wherein the instructions comprise information selected from the group consisting of;

assessing the severity of the idiopathic vomiting condition of the companion animal;

frequency of feeding;

duration of feeding;

mode of feeding; and

monitoring the idiopathic vomiting condition of the companion animal to determine when to modify the frequency or the duration of feeding.

20. The kit of claim 19, wherein the companion animal is a domestic cat.

8. A method for preventing or treating idiopathic vomiting in a companion animal, comprising the step of orally administering to said companion animal one or more plant materials or extracts thereof in an effective amount for inhibiting a 5-hydroxytryptamine-3a serotonin (5-HT3a) receptor and/or a neurokinin-1 (NK-1) receptor.

9. The method of claim 8, wherein said plant materials or extracts have inhibitory effect on the 5-HT3a receptor and are selected from the group consisting of lemon tea tree leaf extract, a water-soluble fraction of tea tree oil, rhubarb, lavender tea tree extract, Australian sandalwood extract, sandalwood oil, evodia fruit, coptis rhizome, oils from Wisteria sinensis, myrtle extract, wild cherry bark, Chinese Agarwood resinous heartwood extract, ginger root, marigold, boswellia, frankincense oil, prickly ash fruit extract, Pinus pinaster bark extract, horehound, bitter orange fruit, angelica, coconut oil, Chinese rose, cinnamon, bilberry, blueberry leaf extract, carrot extract, chamomile extract, turmeric extract, cranberry extract, flax oil powder, Japanese raisin tree seed extract, Andrographis herb extract, bee pollen extract, Australia eucalyptus extract, Yerba santa extract, black pepper oil, Ginkgo biloba extract, cayenne extract, and combinations thereof.

10. The method of claim 8, wherein said plant materials or extracts have inhibitory effect on the 5-HT3a receptor and comprise a combination selected from the group consisting of:

(a) Turmeric and licorice;

(b) Turmeric, licorice, and ginger;

(c) Turmeric and ginger;

(d) Turmeric and rhubarb; and

(e) Licorice, ginger, and rhubarb.

11. The method of claim 8, wherein said plant materials or extracts have inhibitory effect on the NK-1 receptor and are selected from the group consisting of podophyllin, rhodiola, feverfew, pink bark, boswellia, dragon'"'"'s blood, linden, guarana, cat'"'"'s claw, St. John'"'"'s wort, calendula, green tea, grape, cinnamon, turmeric, Forysthia fruit, licorice, Litsea cubeba oil, tea tree oil, amla, and combinations thereof.

12. The method of claim 8, wherein said plant materials or extracts have inhibitory effect on the NK-1 receptor and comprise the combination of turmeric and licorice.

13. The method of claim 8, wherein said one or more plant materials or extracts are orally administered to the companion animal as a part of a dietary composition.

14. The method of claim 13, wherein said dietary composition is a pet food comprising from 0.1 ppm to 75,000 ppm of said one or more plant materials or extracts thereof, and wherein said pet food further comprises a source of carbohydrate, a source of protein, and optionally a source of fat.

15. The method of claim 13, wherein said dietary composition is a pet food supplement comprising from 0.1% to 99% of said one or more plant materials or extracts thereof by weight, and wherein the step of orally administering comprises feeding the pet food supplement to the companion animal either separately from or in combination with a pet food.

16. The method of claim 13, wherein said dietary composition is orally administered to the companion animal at a frequency ranging from once a month to six times a day.

17. The method of claim 13, wherein said dietary composition is orally administered to the companion animal for a duration ranging from five days to twenty five years.

18. A composition for preventing or treating idiopathic vomiting in a companion animal, comprising one or more plant materials or extracts thereof in an effective amount for inhibiting a 5-hydroxytryptamine-3a serotonin (5-HT_3a) receptor and/or a neurokinin-1 (NK-1) receptor.